| Decrease in Circulating Fibroblast Growth Factor 21 after an oral fat load is related to postprandial triglyceride-rich lipoproteins and liver fat. | |
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MedLine Citation:
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PMID: 22190000 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Elevated levels of circulating Fibroblast growth factor 21 (FGF21) are commonly encountered in type 2 diabetes, dyslipidemia and non-alcoholic fatty liver disease, all of which share exaggerated postprandial lipemia as a common proatherogenic feature. How FGF21 responds to an oral fat load in man is unknown.Methods We measured liver fat contents and subcutaneous and visceral fat volumes in 47 healthy subjects, who also underwent an oral fat load with measurements of plasma FGF21, FFA and triglyceride-rich lipoprotein (TRL) TG, apoB-48 and apoB-100.Results As compared to fasting levels, the concentration of FGF21 decreased significantly at 4hrs (P < 0.05) and tended to return to fasting levels at 8hrs after an oral fat load. Fasting and postprandial FGF21 correlated significantly with liver fat as well as with TRLs in the chylomicron and especially in VLDL1 and VLDL2 fractions representing remnant particles, but not with FFA. Subjects with increased liver fat (>5%, n=12) showed impaired suppression of FGF21 at 4hrs (P < 0.05) and at 8hrs (P = 0.01) and demonstrated higher postprandial TG AUC in plasma and TRL fractions (P ≤ 0.032) as compared to those with normal liver fat (≤5%, n=35).Conclusions We observed a significant decrease of FGF21 concentration after an oral fat load. Fasting and postprandial FGF21 levels were closely related to large VLDL and remnants, but not to plasma FFA. Our pilot findings suggest that the postprandial accumulation of TRL remnants and liver fat may modulate postprandial FGF21 levels. |
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Authors:
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Niina Matikainen; Marja-Riitta Taskinen; Sanna Stennabb; Nina Lundbom; Antti Hakkarainen; Kirsi Vaaralahti; Taneli Raivio |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-21 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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N Matikainen, Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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