| Decrease of core body temperature in mice by dehydroepiandrosterone. | |
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MedLine Citation:
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PMID: 12037127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary dehydroepiandrosterone (DHEA) reduces food intake in mice, and this response is under genetic control. Moreover, both food restriction and DHEA can prevent or ameliorate certain diseases and mediate other biological effects. Mice fed DHEA (0.45% w/w of food) and mice pair-fed to these mice (food restricted) for 8 weeks were tested for changes in body temperature. DHEA was more efficient than food restriction alone in causing hypothermia. DHEA injected intraperitoneally also induced hypothermia that reached a nadir at 1 to 2 hr, and slowly recovered by 20 to 24 hr. This effect was dose dependent (0.5-50 mg). Each mouse strain tested (four) was susceptible to this effect, suggesting that the genetics differ for induction of hypophagia and induction of hypothermia. Because serotonin and dopamine can regulate (decrease) body temperature, we treated mice with haloperidol (dopamine receptor antagonist), 5,7-dihydroxytryptamine (serotonin production inhibitor), or ritanserin (serotonin receptor antagonist) prior to injection of DHEA. All of these agents increased rather than decreased the hypothermic effects of DHEA. DHEA metabolites that are proximate (5-androstene-3beta, 17beta-diol and androstenedione) or further downstream (estradiol-17beta) were much less effective than DHEA in inducing hypothermia. However, the DHEA analog, 16alpha-chloroepiandrosterone, was as active as DHEA. Thus, DHEA administered parentally seems to act directly on temperature-regulating sites in the body. These results suggest that DHEA induces hypothermia independent of its ability to cause food restriction, to affect serotonin or dopamine functions, or to act via its downstream steroid metabolites. |
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Authors:
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Fernando Catalina; Leon Milewich; William Frawley; Vinay Kumar; Michael Bennett |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental biology and medicine (Maywood, N.J.) Volume: 227 ISSN: 1535-3702 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-05-30 Completed Date: 2002-06-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: United States |
Other Details:
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Languages: eng Pagination: 382-8 Citation Subset: IM |
Affiliation:
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Departments of Pathology, Obstetrics and Gynecology, and Academic Computing Services, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9072, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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5,7-Dihydroxytryptamine
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pharmacology Androsterone / biosynthesis Animals Body Temperature / drug effects* Dehydroepiandrosterone / pharmacology* Diet Dopamine / metabolism Dopamine Antagonists / pharmacology Dose-Response Relationship, Drug Haloperidol / pharmacology Hypothermia / metabolism Male Mice Mice, Inbred BALB C Ritanserin / pharmacology Serotonin / metabolism Serotonin Agents / pharmacology Serotonin Antagonists / pharmacology Temperature Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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5T32 GM08013/GM/NIGMS NIH HHS; AI20451/AI/NIAID NIH HHS; AI38939/AI/NIAID NIH HHS; CA36822/CA/NCI NIH HHS; CA43311/CA/NCI NIH HHS; CA47073/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Antagonists; 0/Serotonin Agents; 0/Serotonin Antagonists; 31363-74-3/5,7-Dihydroxytryptamine; 50-67-9/Serotonin; 52-86-8/Haloperidol; 53-41-8/Androsterone; 53-43-0/Dehydroepiandrosterone; 87051-43-2/Ritanserin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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