Document Detail


Decrease of core body temperature in mice by dehydroepiandrosterone.
MedLine Citation:
PMID:  12037127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dietary dehydroepiandrosterone (DHEA) reduces food intake in mice, and this response is under genetic control. Moreover, both food restriction and DHEA can prevent or ameliorate certain diseases and mediate other biological effects. Mice fed DHEA (0.45% w/w of food) and mice pair-fed to these mice (food restricted) for 8 weeks were tested for changes in body temperature. DHEA was more efficient than food restriction alone in causing hypothermia. DHEA injected intraperitoneally also induced hypothermia that reached a nadir at 1 to 2 hr, and slowly recovered by 20 to 24 hr. This effect was dose dependent (0.5-50 mg). Each mouse strain tested (four) was susceptible to this effect, suggesting that the genetics differ for induction of hypophagia and induction of hypothermia. Because serotonin and dopamine can regulate (decrease) body temperature, we treated mice with haloperidol (dopamine receptor antagonist), 5,7-dihydroxytryptamine (serotonin production inhibitor), or ritanserin (serotonin receptor antagonist) prior to injection of DHEA. All of these agents increased rather than decreased the hypothermic effects of DHEA. DHEA metabolites that are proximate (5-androstene-3beta, 17beta-diol and androstenedione) or further downstream (estradiol-17beta) were much less effective than DHEA in inducing hypothermia. However, the DHEA analog, 16alpha-chloroepiandrosterone, was as active as DHEA. Thus, DHEA administered parentally seems to act directly on temperature-regulating sites in the body. These results suggest that DHEA induces hypothermia independent of its ability to cause food restriction, to affect serotonin or dopamine functions, or to act via its downstream steroid metabolites.
Authors:
Fernando Catalina; Leon Milewich; William Frawley; Vinay Kumar; Michael Bennett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  227     ISSN:  1535-3702     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-30     Completed Date:  2002-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  382-8     Citation Subset:  IM    
Affiliation:
Departments of Pathology, Obstetrics and Gynecology, and Academic Computing Services, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9072, USA.
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MeSH Terms
Descriptor/Qualifier:
5,7-Dihydroxytryptamine / pharmacology
Androsterone / biosynthesis
Animals
Body Temperature / drug effects*
Dehydroepiandrosterone / pharmacology*
Diet
Dopamine / metabolism
Dopamine Antagonists / pharmacology
Dose-Response Relationship, Drug
Haloperidol / pharmacology
Hypothermia / metabolism
Male
Mice
Mice, Inbred BALB C
Ritanserin / pharmacology
Serotonin / metabolism
Serotonin Agents / pharmacology
Serotonin Antagonists / pharmacology
Temperature
Time Factors
Grant Support
ID/Acronym/Agency:
5T32 GM08013/GM/NIGMS NIH HHS; AI20451/AI/NIAID NIH HHS; AI38939/AI/NIAID NIH HHS; CA36822/CA/NCI NIH HHS; CA43311/CA/NCI NIH HHS; CA47073/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Antagonists; 0/Serotonin Agents; 0/Serotonin Antagonists; 31363-74-3/5,7-Dihydroxytryptamine; 50-67-9/Serotonin; 52-86-8/Haloperidol; 53-41-8/Androsterone; 53-43-0/Dehydroepiandrosterone; 87051-43-2/Ritanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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