Document Detail

Decrease of blood pressure in spontaneously hypertensive mice by heat treatment.
MedLine Citation:
PMID:  2350479     Owner:  NLM     Status:  MEDLINE    
Although the increased sensitivity of hypertensive animals to heat stress has been reported, the effect of chronic heat exposure has not been examined. The specific goal of the present investigation was to study the impact of chronic heat treatment on the blood pressure of spontaneously hypertensive mice. Chronic 40 degrees C heat exposure for 5 min daily progressively lowered basal blood pressure in hypertensive mice within 20 days, without any change in normal mice. In fact, after 35 days of chronic heat treatment, the basal blood pressure of hypertensive mice was indistinguishable from that of the normotensives. Repeated immobilization and prewarming as normal procedures for recording blood pressure contributed to the decrease in blood pressure by 10 to 12 mm Hg, but chronic heat by itself was significantly more potent in reducing it by an additional 20 mm Hg. After the discontinuation of chronic heat application, the basal blood pressure of hypertensive mice returned with time to the level registered in sham-handled hypertensive controls. These results demonstrate that, although acute heat is more detrimental to hypertensive mice, brief, chronic exposure to mild heat stress is beneficial in that it normalizes basal blood pressure.
D Malo; S C Pang; G Schlager; J Tremblay; P Hamet
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  3     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-16     Completed Date:  1990-07-16     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  400-4     Citation Subset:  IM    
Clinical Research Institute of Montreal, Québec, Canada.
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MeSH Terms
Blood Pressure*
Blood Pressure Determination
Handling (Psychology)
Hot Temperature*
Hypertension / genetics,  physiopathology*
Mice, Mutant Strains
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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