Document Detail

Decrease of angiotensin sensitivity after bed rest and strongly sodium-restricted diet in pregnancy.
MedLine Citation:
PMID:  6837658     Owner:  NLM     Status:  MEDLINE    
Angiotensin II (A-II) sensitivity was determined in 23 nonmedicated nulliparas in the third trimester of pregnancy, before and after a 7- to 10-day period of bed rest and a strongly sodium-restricted diet (maximal 20 mmol Na+/24 hr). Seventeen nulliparous women had pregnancy-induced hypertension (PIH). The effective pressor dose (EPD), that is the minimal amount of A-II necessary for a 20 mm Hg elevation of the diastolic blood pressure, rose from a mean of 11.0 +/- 5.0 to 17.9 +/- 5.7 ng/kg/min. This is an increase of the mean of 63%. Six women were normotensive during the course of the pregnancy. They showed an increase of EPD from 12.6 +/- 4.9 to 28.3 +/- 10.9 ng/kg/min after sodium restriction and bed rest. This is a mean increase of 124%. It is concluded from this study that sodium not only is important in volume regulation but also seems to play a role in vessel wall reactivity. This effect of sodium on vascular reactivity could be the explanation for the favorable effect of a strongly sodium-restricted diet in lowering the incidence of eclampsia in women with PIH.
W J Jaspers; P A de Jong; A W Mulder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  145     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  792-6     Citation Subset:  AIM; IM    
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MeSH Terms
Angiotensin II / metabolism*
Bed Rest*
Diet, Sodium-Restricted*
Hypertension / complications,  metabolism*,  therapy
Pregnancy Complications, Cardiovascular / metabolism*,  therapy
Pregnancy Trimester, Third
Sodium / urine
Reg. No./Substance:
11128-99-7/Angiotensin II; 7440-23-5/Sodium

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