Document Detail

Decrease of acid phosphatase activity in murine peritoneal macrophages infected with Leishmania donovani.
MedLine Citation:
PMID:  2592149     Owner:  NLM     Status:  MEDLINE    
The effect of infection with Leishmania donovani on the activity and isoenzyme composition of acid phosphatase within individual murine peritoneal macrophages maintained in vitro was studied. Concentrations of acid phosphatase activity and number of intracellular parasites were quantitated using a computer-assisted cytospectrophotometry system. Changes in the isoenzyme composition of macrophages during infection with L. donovani were detected by comparing the patterns of acid phosphatase levels between macrophages treated in the absence and presence of an enzyme inhibitor. It was observed that the concentration levels of acid phosphatase activity in macrophages were decreased significantly by infection with L. donovani. An inverse relation existed between concentration of acid phosphatase activity and the number of intracellular L. donovani. Reduced concentrations of acid phosphatase activity were also observed in macrophages uninfected but exposed to L. donovani. The isoenzyme composition in macrophages did not change during the course of infection with L. donovani. These results demonstrate that L. donovani reduces the acid phosphatase activity of macrophages.
G Theodoropoulos; J H Theis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal for parasitology     Volume:  19     ISSN:  0020-7519     ISO Abbreviation:  Int. J. Parasitol.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-01-16     Completed Date:  1990-01-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0314024     Medline TA:  Int J Parasitol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  813-6     Citation Subset:  IM    
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MeSH Terms
Acid Phosphatase / analysis*
Isoenzymes / analysis*
Leishmania donovani / physiology*
Macrophages / enzymology,  parasitology*
Mice, Inbred BALB C
Regression Analysis
Reg. No./Substance:
0/Isoenzymes; EC Phosphatase

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