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Decrease Recurrence Rate of Condylomata Acuminata by Photodynamic Therapy Combined with CO(2) Laser in Mainland China: A Meta-Analysis.
MedLine Citation:
PMID:  23406980     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Condylomata acuminata (CA) are caused by human papillomavirus. Most conventional therapies for CA have high recurrence rate. Objectives: To compare the recurrence rate of 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) combined with CO(2) laser and CO(2) laser alone for CA treatment in mainland China. Methods: In this meta-analysis, 2,048 cases of CA from 22 articles were divided into two groups. The treatment group was treated by using ALA-PDT combined with CO(2) laser, and CO(2) laser alone was applied in the control group. The recurrence rate of the two groups was calculated and compared. Results: The recurrence rate was 42.67% (451/1,057) in the control group and 10.29% (102/991) in the treatment group, with a significant statistical difference between the two groups (χ(2) = 271.98, p < 0.0001). Conclusion: ALA-PDT combined with CO(2) laser was more effective in decreasing the recurrence rate of CA compared with CO(2) laser alone. It might offer a wide clinical application for CA treatment.
Authors:
Xiaoling Zhu; Hongxiao Chen; Longfeng Cai; Zhiming Yu; Limin Cai
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-12
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  -     ISSN:  1421-9832     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  364-370     Citation Subset:  -    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Affiliation:
Department of Pathology, Basic Medical Science College, Harbin Medical University, Harbin, China.
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