Document Detail


Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers.
MedLine Citation:
PMID:  23355085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.
Authors:
Ruogang Zhao; Thomas Boudou; Wei-Gang Wang; Christopher S Chen; Daniel H Reich
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-28
Journal Detail:
Title:  Advanced materials (Deerfield Beach, Fla.)     Volume:  25     ISSN:  1521-4095     ISO Abbreviation:  Adv. Mater. Weinheim     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-10     Revised Date:  2014-05-29    
Medline Journal Info:
Nlm Unique ID:  9885358     Medline TA:  Adv Mater     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1699-705     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanical Phenomena
Collagen / metabolism
Magnetic Phenomena*
Mechanical Processes*
Mice
Microtechnology / methods*
NIH 3T3 Cells
Tissue Engineering / methods*
Grant Support
ID/Acronym/Agency:
HL90747/HL/NHLBI NIH HHS; P30 ES00319/ES/NIEHS NIH HHS; R01 GM074048/GM/NIGMS NIH HHS; R01 HL073305/HL/NHLBI NIH HHS; R01 HL090747/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9007-34-5/Collagen
Comments/Corrections

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