| Deconvolution of isobaric interferences in mass spectra. | |
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MedLine Citation:
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PMID: 15121194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The concept of isobar deconvolution using the mass domain and signal intensity based domains is described. The intensity domain-based approach employs the reconstruction of the observed isotope pattern from the isolated patterns of the isobaric species. The quantitative information is adjusted with the use of the least squares algorithm. The mass domain-based approach employs signal deconvolution by forming Gaussian components for which the peak width and position can be predicted a priori. The latter method is applicable to medium resolution instruments, such as TOF-MS, while the pattern reconstruction approach is applicable also to low resolution instrumentation, such as quadrupole-based ICP-MS or GC/MS. An example of CH(z)Se (z = 0-4) cluster analysis in dimethyl diselenide mass spectra is given to illustrate the concepts underlying both approaches. |
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Authors:
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Juris Meija; Joseph A Caruso |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the American Society for Mass Spectrometry Volume: 15 ISSN: 1044-0305 ISO Abbreviation: J. Am. Soc. Mass Spectrom. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-03 Completed Date: 2004-06-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9010412 Medline TA: J Am Soc Mass Spectrom Country: United States |
Other Details:
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Languages: eng Pagination: 654-8 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221-0172, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Isotopes Mass Spectrometry / methods* Models, Molecular Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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ES04908/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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