Document Detail


Decontamination and detoxification strategies for the Fusarium mycotoxin deoxynivalenol in animal feed and the effectiveness of microbial biodegradation.
MedLine Citation:
PMID:  20234966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trichothecenes are a group of mycotoxins mainly produced by fungi of the Fusarium genus. Deoxynivalenol (DON) is one of the most abundant and important trichothecenes in food and feed, and is a significant contaminants due to its frequent occurrence in toxicologically relevant concentrations worldwide. Since toxin production depends strongly on environmental conditions, such as temperature and humidity, Fusarium toxin contamination can not be avoided completely. Therefore, exposure to this toxin is a permanent health risk for both humans and farm animals. As cereal crops are commonly contaminated with DON and animal diets consist mainly of cereals, it can be assumed that animals are frequently exposed to DON-contaminated feeds. Many strategies can be undertaken to reduce the toxic effect of DON. In addition to the general necessity for minimizing all risk factors that might influence the contamination of cereals with DON, such as the so-called field toxins before harvest, several post-harvest strategies can be applied to counteract possible deleterious effects of this mycotoxin in farm animals. Another approach for decontamination in feedstuffs is the use of adsorbent materials. Adsorbent materials may bind mycotoxins in the gastrointestinal tract and reduce absorption and systemic toxicity. It has been shown that some adsorbents are suitable to alleviate the toxic effects of specific mycotoxins, but its efficacy against trichothecenes is practically zero. Therefore, alternative strategies to reduce animal and human health risk are needed. The use of microbial additives is a method which uses microorganisms having the capability to detoxify mycotoxins by metabolism or degradation prior to their resorption in the gastrointestinal tract. DON has been reported to be completely transformed to de-epoxy-DON by ruminal and intestinal microflora. Eubacterium BBSH 797 was capable of DON degradation and counteracted the toxic effects of DON in animals. This review focuses on the efficacy of microbial feed additives in ameliorating the toxic effects of DON. According to the results of experiments to date, it appears that microorganisms are the main living organisms suitable for this mycotoxin biodegradation. However, the use of this approach depends on its effectiveness from both a practical and economic perspective.
Authors:
Wageha A Awad; Khaled Ghareeb; Josef Bohm; Jurgen Zentek
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  27     ISSN:  1944-0057     ISO Abbreviation:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-17     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  England    
Other Details:
Languages:  eng     Pagination:  510-20     Citation Subset:  IM    
Affiliation:
Institute of Nutrition, Department of Veterinary Public Health and Food Science, University of Veterinary Medicine, A-1210 Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Animal Feed / analysis*
Animals
Bacteria / metabolism*
Cereals / chemistry
Chickens / microbiology
Eubacterium / metabolism
Food Contamination / prevention & control*
Gastrointestinal Tract / metabolism,  microbiology
Humans
Metabolic Detoxication, Drug
Rumen / microbiology
Trichothecenes / analysis*,  metabolism*,  toxicity
Chemical
Reg. No./Substance:
0/Trichothecenes; 51481-10-8/deoxynivalenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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