Document Detail


Deconstruction and Dynamical Robustness of Regulatory Networks: Application to the Yeast Cell Cycle Networks.
MedLine Citation:
PMID:  23188157     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Analyzing all the deterministic dynamics of a Boolean regulatory network is a difficult problem since it grows exponentially with the number of nodes. In this paper, we present mathematical and computational tools for analyzing the complete deterministic dynamics of Boolean regulatory networks. For this, the notion of alliance is introduced, which is a subconfiguration of states that remains fixed regardless of the values of the other nodes. Also, equivalent classes are considered, which are sets of updating schedules which have the same dynamics. Using these techniques, we analyze two yeast cell cycle models. Results show the effectiveness of the proposed tools for analyzing update robustness as well as the discovery of new information related to the attractors of the yeast cell cycle models considering all the possible deterministic dynamics, which previously have only been studied considering the parallel updating scheme.
Authors:
Eric Goles; Marco Montalva; Gonzalo A Ruz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-28
Journal Detail:
Title:  Bulletin of mathematical biology     Volume:  -     ISSN:  1522-9602     ISO Abbreviation:  Bull. Math. Biol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401404     Medline TA:  Bull Math Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez, Av. Diagonal las Torres 2640, Peñalolén, Santiago, Chile, eric.chacc@uai.cl.
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