| Deconstructing obesity: the face of fatness before and after the discovery of leptin. | |
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MedLine Citation:
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PMID: 22002009 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The prevalence and severity of obesity have increased to epidemic proportions around the globe, and over two-thirds of the US population grapples with either being overweight or obese. Obesity and its comorbidities not only subtract from quality of overall life, but also claim a substantial cost to life. In this edition of 'Then and now', two seminal papers by D.L. Coleman, 'The influence of genetic background on the expression of the obese (ob) gene in the mouse' and 'Effects of parabiosis of obese with diabetes and normal mice', which featured in Diabetologia in 1973, are appraised for their merit and foresight regarding the present eruption of research into what has consequently been labelled 'the metabolic syndrome'. These two studies determined that a then-unknown circulating factor was responsible for the obese/diabetic state of the ob/ob mouse by using a parabiosis model. This circulating factor was later dubbed 'leptin'. The present commentary juxtaposes the astute deduction and simple methods used over 35 years ago and modern research methods as we go forth in our effort to successfully treat and prevent obesity, diabetes and their co-morbidities. |
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Authors:
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B E Grayson; R J Seeley |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-15 |
Journal Detail:
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Title: Diabetologia Volume: - ISSN: 1432-0428 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Metabolic Diseases Institute, University of Cincinnati, 2170 E. Galbraith Road, Cincinnati, OH, 45237, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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