Document Detail

Decongestant use during pregnancy and its association with preterm delivery.
MedLine Citation:
PMID:  20672347     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite the frequent intake of decongestants during pregnancy, only one study to date has evaluated the association of decongestants with preterm delivery, and it identified a reduced risk. We examined this association in more detail.
METHODS: Using a population-based random sample of 3271 Massachusetts live-born births without major malformations, we categorized decongestant exposure according to timing, frequency of use, route, and indication. Preterm birth was defined as a gestational age of <37 completed weeks. We estimated hazard ratios and examined confounding by indication by examining various strata of women and through multivariate adjustment.
RESULTS: Compared to nonexposed women, those who took decongestants during the second or third trimester only were less likely to experience preterm delivery (HR, 0.42; 95% CI, 0.21-0.84). This association was observed only for women without preeclampsia.
CONCLUSIONS: A protective association between decongestant use and preterm delivery has now been observed in two studies; however, the possibility of confounding by underlying condition remains.
Rohini K Hernandez; Allen A Mitchell; Martha M Werler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  88     ISSN:  1542-0760     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  715-21     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc.
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
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MeSH Terms
Cohort Studies
Confounding Factors (Epidemiology)
Delivery, Obstetric
Gestational Age
Nasal Decongestants / therapeutic use*
Obstetric Labor, Premature*
Parturition / drug effects*
Phenylpropanolamine / therapeutic use
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Pseudoephedrine / therapeutic use
Retrospective Studies
Rhinitis / drug therapy*
Risk Factors
Reg. No./Substance:
0/Nasal Decongestants; 14838-15-4/Phenylpropanolamine; 90-82-4/Pseudoephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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