| Decongestant use during pregnancy and its association with preterm delivery. | |
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MedLine Citation:
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PMID: 20672347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Despite the frequent intake of decongestants during pregnancy, only one study to date has evaluated the association of decongestants with preterm delivery, and it identified a reduced risk. We examined this association in more detail. METHODS: Using a population-based random sample of 3271 Massachusetts live-born births without major malformations, we categorized decongestant exposure according to timing, frequency of use, route, and indication. Preterm birth was defined as a gestational age of <37 completed weeks. We estimated hazard ratios and examined confounding by indication by examining various strata of women and through multivariate adjustment. RESULTS: Compared to nonexposed women, those who took decongestants during the second or third trimester only were less likely to experience preterm delivery (HR, 0.42; 95% CI, 0.21-0.84). This association was observed only for women without preeclampsia. CONCLUSIONS: A protective association between decongestant use and preterm delivery has now been observed in two studies; however, the possibility of confounding by underlying condition remains. |
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Authors:
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Rohini K Hernandez; Allen A Mitchell; Martha M Werler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 88 ISSN: 1542-0760 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 715-21 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA. rohinikh@bu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Confounding Factors (Epidemiology) Delivery, Obstetric Female Gestational Age Humans Massachusetts Nasal Decongestants / therapeutic use* Obstetric Labor, Premature* Parturition / drug effects* Phenylpropanolamine / therapeutic use Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third Pseudoephedrine / therapeutic use Questionnaires Retrospective Studies Rhinitis / drug therapy* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Nasal Decongestants; 14838-15-4/Phenylpropanolamine; 90-82-4/Pseudoephedrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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