Document Detail

Decompressive craniectomy after intravenous tissue plasminogen activator administration for stroke.
MedLine Citation:
PMID:  22502785     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Intravenous tissue plasminogen activator (IV tPA) is an approved treatment for acute ischemic stroke. However, the effects of decompressive craniectomy (DC) after IV tPA administration for ischemic stroke are still largely unknown. The aim of this study was to investigate the safety and outcomes of DC after IV tPA administration. METHODS: We retrospectively reviewed patients who underwent DC for malignant hemispheric infarction. We compared 20 patients who underwent DC after IV tPA administration with another 20 patients who underwent DC without prior IV tPA administration. RESULTS: The patient characteristics did not differ between the DC patients with and without prior IV tPA administration. New intracranial bleeding or worsening of pre-existing ICH occurred in two patients (10%) in each group. Furthermore, the rates of an mRS score of 4-6, 5 or 6, and 6 did not differ significantly between the two groups. CONCLUSION: DC may be a safe and useful surgical procedure for space-occupying edema after IV tPA administration for acute stroke.
Satoru Takeuchi; Kojiro Wada; Hiroshi Nawashiro; Hirohiko Arimoto; Hidenori Ohkawa; Hiroyuki Masaoka; Naoki Otani; Yoshio Takasato
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-11
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  -     ISSN:  1872-6968     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Department of Neurosurgery, National Defense Medical College, Saitama, Japan.
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