| Decomposition of thimerosal in aqueous solution and its determination by high-performance liquid chromatography. | |
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MedLine Citation:
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PMID: 6663475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies on the decomposition of thimerosal in aqueous solution have confirmed that thiosalicylic acid and ethylmercuric hydroxide are the initial products. On prolonged reaction, thiosalicylic acid was oxidized to 2,2'-dithiosalicylic acid, while ethylmercuric hydroxide was reduced to elemental mercury. As a result, a specific, reverse-phase high-performance liquid chromatographic assay has been developed for thimerosal in the presence of its decomposition products. By comparison, an existing colorimetric assay procedure employing dithizone was shown to be not fully specific. The presence of sodium chloride in the solution accelerated the decomposition of thimerosal. There was evidence that thimerosal was sorbed onto plastic containers on storage. |
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Authors:
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M J Reader; C B Lines |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 72 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-03-16 Completed Date: 1984-03-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1406-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzoates Chemical Phenomena Chemistry Chromatography, High Pressure Liquid / methods Colorimetry / methods Dithizone / analysis Drug Stability Drug Storage Ethylmercury Compounds / analysis* Hydrolysis Solutions Sulfhydryl Compounds Temperature Thimerosal / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Benzoates; 0/Ethylmercury Compounds; 0/Solutions; 0/Sulfhydryl Compounds; 147-93-3/2-thiosalicylic acid; 54-64-8/Thimerosal; 60-10-6/Dithizone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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