Document Detail

Decomposition of cocoa procyanidins in the gastric milieu.
MedLine Citation:
PMID:  10872833     Owner:  NLM     Status:  MEDLINE    
There is considerable interest in the bioavailability of flavonoids and phenolic components of the diet and their bioactivity in vivo. However, little is known of pre-absorption events in the gastric lumen. The effects of the acidic environment, as found in the gastric milieu, on procyanidin oligomers of catechin polyphenols has been investigated. The results show that under these conditions the procyanidin oligomers (trimer to hexamer) are hydrolysed to mixtures of epicatechin monomer and dimer, thus enhancing the potential for their absorption in the small intestine.
J P Spencer; F Chaudry; A S Pannala; S K Srai; E Debnam; C Rice-Evans
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  272     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-17     Completed Date:  2000-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  236-41     Citation Subset:  IM    
Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College, London, United Kingdom.
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MeSH Terms
Biological Availability
Cacao / chemistry*
Catechin / chemistry,  pharmacokinetics*
Chromatography, High Pressure Liquid
Gastric Juice / metabolism*
Hydrogen-Ion Concentration
Ileum / metabolism
Intestinal Absorption
Jejunum / metabolism
Reg. No./Substance:
0/Biflavonoids; 0/Proanthocyanidins; 154-23-4/Catechin; 4852-22-6/procyanidin

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