Document Detail


Decompensated chronic heart failure: increased liver stiffness measured by means of transient elastography.
MedLine Citation:
PMID:  20935077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To analyze transient elastography-measured liver stiffness in patients with acute decompensated heart failure to describe variations in liver stiffness measurements and assess their relationship with the patients' clinical course and laboratory data.
MATERIALS AND METHODS: This study was approved by the local institutional review board, and all of the subjects gave verbal informed consent. Twenty-seven hospitalized patients with heart failure with no signs of liver disease (mean age, 79 years ± 12 [standard deviation]; 12 men [mean age, 78 years ± 11], 15 women [mean age, 80 years ± 12]) underwent liver stiffness and N-terminal proβ brain natriuretic peptide (NTproβBNP) assessments at admission, and 24 patients underwent stiffness measurements at discharge. (Three patients had failed measurement at admission; two of whom did not undergo measurement at discharge and one patient who died had only an admission value obtained.) The predefined stiffness cutoff values were greater than 7.65 kPa for substantial fibrosis and greater than 13.01 kPa for cirrhosis. The control subjects were 21 patients unaffected by heart failure or liver disease. The two groups were compared by using two-tailed Wilcoxon, Mann-Whitney, or t tests, as appropriate.
RESULTS: Among the patients with heart failure, median liver stiffness at admission was 8.80 kPa (interquartile range, 5.92-11.90 kPa), greater than 7.65 kPa in 14 (58%) cases and greater than 13.01 kPa in five (21%). During hospitalization, liver stiffness decreased in 18 patients (including all five patients with baseline measurement > 13.01 kPa) and increased in five. Median liver stiffness (P < .003) and NTproβBNP (P < .001) levels both significantly decreased during hospitalization. Liver stiffness was less than 7.65 kPa in all control patients and did not significantly change during hospitalization (P = .261).
CONCLUSION: Most patients with acute decompensated heart failure have high liver stiffness values which, like NTproβBNP levels, tend to decrease with clinical improvement.
SUPPLEMENTAL MATERIAL: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100013/-/DC1.
Authors:
Agostino Colli; Pietro Pozzoni; Alessandra Berzuini; Alessandro Gerosa; Cristina Canovi; Edoardo Ennio Molteni; Marco Barbarini; Ferruccio Bonino; Daniele Prati
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Publication Detail:
Type:  Journal Article     Date:  2010-10-08
Journal Detail:
Title:  Radiology     Volume:  257     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  872-8     Citation Subset:  AIM; IM    
Copyright Information:
© RSNA, 2010
Affiliation:
Department of Medicine, A. Manzoni Hospital, Via Dell'Eremo 9-11, Lecco 23900, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Case-Control Studies
Elasticity Imaging Techniques / methods*
Female
Heart Failure / complications*
Humans
Liver Diseases / pathology,  ultrasonography*
Male
Prospective Studies

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