| Decoding of retinal ganglion cell spike trains evoked by temporally patterned electrical stimulation. | |
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MedLine Citation:
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PMID: 20599822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For successful restoration of vision by retinal prostheses, the neural activity of retinal ganglion cells (RGCs) evoked by electrical stimulation should represent the information of spatiotemporal patterns of visual input. We propose a method to evaluate the effectiveness of stimulation pulse trains so that the crucial temporal information of a visual input is accurately represented in the RGC responses as the amplitudes of pulse trains are modulated according to the light intensity. This was enabled by spike train decoding. The effectiveness of the stimulation was evaluated by the accuracy of decoding pulse amplitude from the RGC spike train, i.e., by the similarity between the original and the decoded pulse amplitude time series. When the parameters of stimulation were suitably determined, the RGC responses were reliably modulated by varying the amplitude of electrical pulses. Accordingly, the temporal pattern of pulse amplitudes could be successfully decoded from multiunit RGC spike trains. The range of pulse amplitude and the pulse rate were critical for accurate representation of input information in RGC responses. These results suggest that pulse amplitude modulation is a feasible means to encode temporal visual information by RGC spike trains and thus to implement stimulus encoding strategies for retinal prostheses. |
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Authors:
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Sang Baek Ryu; Jang Hee Ye; Yong Sook Goo; Chi Hyun Kim; Kyung Hwan Kim |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-01 |
Journal Detail:
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Title: Brain research Volume: 1348 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-29 Completed Date: 2010-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 71-83 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biomedical Engineering, College of Health Science, Yonsei University, 234 Maeji-ri, Heungup-myun, Wonju, Kangwon-do 220-710, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology* Animals Biophysical Processes / physiology Electric Stimulation / methods* Male Rabbits Retina / cytology* Retinal Ganglion Cells / physiology* |
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