Document Detail


Decoding the memorization of individual stimuli with direct human brain recordings.
MedLine Citation:
PMID:  23298746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Through decades of research, neuroscientists and clinicians have identified an array of brain areas that each activate when a person views a certain category of stimuli. However, we do not have a detailed understanding of how the brain represents individual stimuli within a category. Here we used direct human brain recordings and machine-learning algorithms to characterize the distributed patterns that distinguish specific cognitive states. Epilepsy patients with surgically implanted electrodes performed a working-memory task and we used machine-learning algorithms to predict the identity of each viewed stimulus. We found that the brain's representation of stimulus-specific information is distributed across neural activity at multiple frequencies, electrodes, and timepoints. Stimulus-specific neuronal activity was most prominent in the high-gamma (65-128 Hz) and theta/alpha (4-16 Hz) bands, but the properties of these signals differed significantly between individuals and for novel stimuli compared to common ones. Our findings are helpful for understanding the neural basis of memory and developing brain-computer interfaces by showing that the brain distinguishes specific cognitive states by diverse spatiotemporal patterns of neuronal.
Authors:
Marcel A J van Gerven; Eric Maris; Michael Sperling; Ashwini Sharan; Brian Litt; Christopher Anderson; Gordon Baltuch; Joshua Jacobs
Related Documents :
20570486 - Persons with multiple disabilities use orientation technology to find room entrances du...
18509336 - Analysis of a spatial orientation memory in drosophila.
18484846 - Offline processing of memories induced by perceptual visual learning during subsequent ...
16263646 - Attentional deficits in concussion.
15000536 - Nonintentional task set activation: evidence from implicit task sequence learning.
20408046 - The cambridge semantic memory test battery: detection of semantic deficits in semantic ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-05
Journal Detail:
Title:  NeuroImage     Volume:  70     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-09-23     Revised Date:  2014-04-16    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cerebral Cortex / physiopathology*
Electroencephalography
Epilepsy / physiopathology*
Humans
Memory, Short-Term / physiology*
Grant Support
ID/Acronym/Agency:
R01 MH055687/MH/NIMH NIH HHS; R01 NS048598/NS/NINDS NIH HHS; R01MH55687/MH/NIMH NIH HHS; R21NS067316/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Past tense in the brain's time: neurophysiological evidence for dual-route processing of past-tense ...
Next Document:  Interpretable Whole-Brain Prediction Analysis with GraphNet.