Document Detail


Decoding the LIM development code.
MedLine Citation:
PMID:  12813919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During development a vast number of distinct cell types arise from dividing progenitor cells. Concentration gradients of ligands that act via cell surface receptors signal transcriptional regulators that repress and activate particular genes. LIM homeodomain proteins are an important class of transcriptional regulators that direct cell fate. Although in C. elegans only a single LIM homeodomain protein is expressed in a particular cell type, in vertebrates combinations of LIM homeodomain proteins are expressed in cells that determine cell fates. We have investigated the molecular basis of the LIM domain "code" that determines cell fates such as wing formation in Drosophilia and motor neuron formation in chicks. The basic code is a homotetramer of 2 LIM homeodomain proteins bridged by the adaptor protein, nuclear LIM interactor (NLI). A more complex molecular language consisting of a hexamer complex involving NLI and 2 LIM homeodomain proteins, Lhx3 and Isl1 determines ventral motor neuron formation. The same molecular "words" adopt different meanings depending on the context of expression of other molecular "words."
Authors:
Gordon N Gill
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Transactions of the American Clinical and Climatological Association     Volume:  114     ISSN:  0065-7778     ISO Abbreviation:  Trans. Am. Clin. Climatol. Assoc.     Publication Date:  2003  
Date Detail:
Created Date:  2003-06-19     Completed Date:  2003-07-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7507559     Medline TA:  Trans Am Clin Climatol Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-89     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Chick Embryo
DNA-Binding Proteins / genetics,  physiology
Drosophila / genetics,  growth & development
Drosophila Proteins / genetics,  physiology
Gene Expression Regulation, Developmental
Genes, Homeobox
Genes, Insect
Homeodomain Proteins / genetics*,  physiology*
Interneurons / cytology
Molecular Sequence Data
Motor Neurons / cytology
Wing / growth & development
Grant Support
ID/Acronym/Agency:
DK13149/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Homeodomain Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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