Document Detail


Declining HCV seroprevalence in pregnant women with HIV.
MedLine Citation:
PMID:  20096149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed recent trends in hepatitis C virus (HCV) prevalence in pregnant women with HIV using data from a large national study. Based on 1240 pregnancies, we observed a 3.4-fold decline in HCV seroprevalence in pregnant women with HIV between 2001 (29.3%) and 2008 (8.6%). This decline was the net result of two components: a progressively declining HCV seroprevalence in non-African women (from 35.7% in 2001 to 16.7% in 2008), sustained by a parallel reduction in history of injecting drug use (IDU) in this population, and a significantly growing presence (from 21.2% in 2001 to 48.6% in 2008) of women of African origin, at very low risk of being HCV-infected [average HCV prevalence 1%, adjusted odds ratio (aOR) for HCV 0.09, 95% CI 0.03-0.29]. Previous IDU was the stronger determinant of HCV co-infection in pregnant women with HIV (aOR 30.9, 95% CI 18.8-51.1). The observed trend is expected to translate into a reduced number of cases of vertical HCV transmission.
Authors:
M Floridia; E Tamburrini; G Anzidei; C Tibaldi; M L Muggiasca; G Guaraldi; M Fiscon; A Vimercati; P Martinelli; A Donisi; S Dalzero; M Ravizza;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-25
Journal Detail:
Title:  Epidemiology and infection     Volume:  138     ISSN:  1469-4409     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  1317-21     Citation Subset:  IM    
Affiliation:
Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy. floridia@iss.it
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MeSH Terms
Descriptor/Qualifier:
Chi-Square Distribution
Female
HIV Infections / epidemiology*
Hepatitis C / epidemiology*
Humans
Italy / epidemiology
Logistic Models
Pregnancy
Risk Factors
Seroepidemiologic Studies
Investigator
Investigator/Affiliation:
M Ravizza / ; E Tamburrini / ; P Ortolani / ; F Mori / ; C Monticelli / ; E R dalle Nogare / ; G Sterrantino / ; M Meli / ; S Polemi / ; J Nocentini / ; M Baldini / ; G Montorzi / ; M Mazzetti / ; B Borchi / ; E Rubino / ; A Bucceri / ; R Matrone / ; G Scaravelli / ; G Anzidei / ; S Di Giambenedetto / ; C Fundaro / ; O Genovese / ; C Cafforio / ; C Pinnetti / ; G Liuzzi / ; V Tozzi / ; P Massetti / ; M Anceschi / ; A M Casadei / ; F Montella / ; A F Cavaliere / ; V Finelli / ; C Riva / ; L Lazier / ; M Cellini / ; S Garetto / ; G Castelli Gattinara / ; A M Marconi / ; M Ierardi / ; S Foina / ; B Salerio / ; S Dalzero / ; M Moneta / ; C Polizzi / ; A Mattei / ; M F Pirillo / ; R Amici / ; C M Galluzzo / ; S Donnini / ; S Baroncell / ; M Floridia / ; M Regazzi / ; P Villani / ; M Cusato / ; A Cerioli / ; M De Martino / ; P Mastroiacovo / ; M Moroni / ; E Parazzini / ; S Vella / ; E Ferrazzi / ; P Martinelli /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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