Document Detail

Decline in respiratory syncytial virus hospitalizations in a region with high hospitalization rates and prolonged season.
MedLine Citation:
PMID:  17133156     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: During 1993 to 1996, Alaska Native infants <1 year of age from the Yukon Kuskokwim (YK) Delta in Alaska experienced a respiratory syncytial virus (RSV) hospitalization rate 5 times the U.S. general infant population rate. We describe trends in lower respiratory tract infection (LRTI) and RSV hospitalizations in YK children from 1994 to 2004. METHODS: We abstracted hospital dates, RSV test results and clinical information from the hospital records for YK children <3 years of age hospitalized between July 1994 and June 2004. RESULTS:: The RSV hospitalization rate in YK Delta children <1 year of age decreased from 178 per 1000 infants per year (1994-1997) to 104 per 1000 infants per year (2001-2004) (P < 0.001), and the RSV hospitalization rate for premature infants decreased from 317 to 123 per 1000 infants per year (P < 0.001). The risk reduction for RSV hospitalization was greater in premature (relative risk, 0.39) than in term infants (relative risk, 0.60; P = 0.04). The rate of non-RSV LRTI hospitalizations increased from 153 to 215 per 1000 infants per year (P < 0.001). The median RSV season length was 30.5 weeks. Pneumonia was diagnosed in more than half of RSV admissions. CONCLUSIONS: In YK infants, the RSV hospitalization rate decreased by one-third between 1994 and 2004; however, the overall LRTI hospitalization rate did not change. The median RSV season was twice as long as for the U.S. population. Palivizumab prophylaxis may be responsible for the larger decrease in the RSV hospitalization rate among premature infants; however, the 2001-2004 RSV hospitalization rate among YK infants remained 3 times higher than the U.S. infant rate.
Rosalyn J Singleton; Dana Bruden; Lisa R Bulkow; Gilbert Varney; Jay C Butler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  25     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-29     Completed Date:  2007-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1116-22     Citation Subset:  IM    
Alaska Native Tribal Health Consortium, Anchorage, AK, USA.
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MeSH Terms
Alaska / epidemiology
Antibodies, Monoclonal / therapeutic use
Antiviral Agents / therapeutic use
Child, Preschool
Hospitalization / statistics & numerical data*
Infant, Newborn
Infant, Premature, Diseases / epidemiology,  prevention & control
Pneumonia, Viral / epidemiology,  prevention & control,  virology
Respiratory Syncytial Virus Infections / epidemiology*,  prevention & control,  virology*
Respiratory Syncytial Viruses / isolation & purification*
Respiratory Tract Infections / epidemiology*,  prevention & control,  virology
Time Factors
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antiviral Agents; 0/palivizumab

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