Document Detail

Decline in the incidence of schizophrenia in Finnish cohorts born from 1954 to 1965.
MedLine Citation:
PMID:  10435608     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The declining incidence of schizophrenia observed in several countries is believed by many to merely reflect methodological problems in the studies performed. We report the first nationwide historical cohort study of changes in the incidence of schizophrenia, in which many of the previous methodological problems were overcome. METHODS: We used the Finnish Population Register to identify everyone born in Finland from 1954 to 1965. These persons were followed up from their 16th to their 26th birthdays, and all cases of schizophrenia (International Classification of Diseases, Eighth Revision and International Classification of Diseases, Ninth Revision code 295) that emerged were identified from the National Hospital Discharge Register, the Pension Register, and the Free Medicine Register. Persons for whom an age of onset could be defined were included in the analyses (n = 5645). We used the Poisson regression model to estimate the effects of age, sex, birth cohort, period of diagnosis, and season of birth on the incidence of schizophrenia. The relative importance of cohort and period were assessed using an age-period-cohort model. RESULTS: The incidence declined significantly in each successive cohort, from 0.79 to 0.53 per 1000 among males and from 0.58 to 0.41 per 1000 among females. The effects of cohort and period on the change were both significant. CONCLUSIONS: The incidence of schizophrenia has declined in Finland. This was partly caused by confounding factors, as reflected in the significant period effect. The significant birth cohort effect suggests that the intensity or frequency of one or more risk factors for schizophrenia has decreased.
J M Suvisaari; J K Haukka; A J Tanskanen; J K Lönnqvist
Related Documents :
10565498 - Exposure to prenatal and childhood infections and the risk of schizophrenia: suggestion...
17641528 - Subjective memory complaints: presence, severity and future outcome in normal older sub...
10751108 - Vascular risk factors in dementia.
17515538 - Cycad exposure and risk of dementia, mci, and pdc in the chamorro population of guam.
6651238 - Prognosis of ocular myasthenia.
22264078 - Health education intervention in early and late postmenopausal brazilian women.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  56     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-11     Completed Date:  1999-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  733-40     Citation Subset:  AIM; IM    
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Age of Onset
Birth Rate
Cohort Studies
Confounding Factors (Epidemiology)
Finland / epidemiology
Follow-Up Studies
Registries / statistics & numerical data
Regression Analysis
Risk Factors
Schizophrenia / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  First onset of depressive or anxiety disorders predicted by the longitudinal course of internalizing...
Next Document:  Neurobehavioral deficits at adolescence in children at risk for schizophrenia: The Jerusalem Infant ...