| Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study. | |
| | |
MedLine Citation:
|
PMID: 21895960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In current protocols for the medical management of ectopic pregnancies, the first indication of treatment response is obtained no sooner than day 7. We examined whether human chorionic gonadotrophin (βhCG) trends between days 0 and 4 after methotrexate provide an earlier indication of the likely outcome. Of 33 patients where serum βhCG dropped between days 0 and 4 after methotrexate, the ectopic pregnancy was resolved in 88% of cases without further treatment. Of 12 women where serum βhCG rose between days 0 and 4, only 42% had treatment success. A fall in βhCG between days 0 and 4 after treatment with methotrexate for ectopic pregnancy predicts a high likelihood of treatment success. |
| | |
Authors:
|
M M Skubisz; J Li; J Lee; E M Wallace; S Tong |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-09-06 |
Journal Detail:
|
Title: BJOG : an international journal of obstetrics and gynaecology Volume: 118 ISSN: 1471-0528 ISO Abbreviation: BJOG Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-11-14 Completed Date: 2011-12-27 Revised Date: 2012-03-19 |
Medline Journal Info:
|
Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
|
Languages: eng Pagination: 1665-8 Citation Subset: AIM; IM |
Copyright Information:
|
© 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG. |
Affiliation:
|
The Ritchie Centre, Monash Institute of Medical Research, Monash University, Monash Medical Centre, Clayton, Vic., Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortifacient Agents, Nonsteroidal
/
administration & dosage* Biological Markers / metabolism Chorionic Gonadotropin, beta Subunit, Human / metabolism* Female Humans Methotrexate / administration & dosage* Pregnancy Pregnancy, Ectopic / drug therapy*, metabolism Retrospective Studies Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Abortifacient Agents, Nonsteroidal; 0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 59-05-2/Methotrexate |
| Comments/Corrections | |
Comment In:
|
BJOG. 2011 Dec;118(13):i-ii
[PMID:
22077266
]
BJOG. 2012 Mar;119(4):506; author reply 506-7 [PMID: 22324925 ] |
Erratum In:
|
BJOG. 2012 Jan;119(1):123 Note: Lee, J [corrected to Li, J] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: What women want. Women's preferences for the management of low-grade abnormal cervical screening tes...
Next Document: Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regu...