Document Detail

Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study.
MedLine Citation:
PMID:  21895960     Owner:  NLM     Status:  MEDLINE    
In current protocols for the medical management of ectopic pregnancies, the first indication of treatment response is obtained no sooner than day 7. We examined whether human chorionic gonadotrophin (βhCG) trends between days 0 and 4 after methotrexate provide an earlier indication of the likely outcome. Of 33 patients where serum βhCG dropped between days 0 and 4 after methotrexate, the ectopic pregnancy was resolved in 88% of cases without further treatment. Of 12 women where serum βhCG rose between days 0 and 4, only 42% had treatment success. A fall in βhCG between days 0 and 4 after treatment with methotrexate for ectopic pregnancy predicts a high likelihood of treatment success.
M M Skubisz; J Li; J Lee; E M Wallace; S Tong
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-06
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  118     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-14     Completed Date:  2011-12-27     Revised Date:  2012-03-19    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1665-8     Citation Subset:  AIM; IM    
Copyright Information:
© 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.
The Ritchie Centre, Monash Institute of Medical Research, Monash University, Monash Medical Centre, Clayton, Vic., Australia.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*
Biological Markers / metabolism
Chorionic Gonadotropin, beta Subunit, Human / metabolism*
Methotrexate / administration & dosage*
Pregnancy, Ectopic / drug therapy*,  metabolism
Retrospective Studies
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 59-05-2/Methotrexate
Comment In:
BJOG. 2011 Dec;118(13):i-ii   [PMID:  22077266 ]
BJOG. 2012 Mar;119(4):506; author reply 506-7   [PMID:  22324925 ]
Erratum In:
BJOG. 2012 Jan;119(1):123
Note: Lee, J [corrected to Li, J]

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