Document Detail

Decline in age-dependent, MK801-induced injury coincides with developmental switch in parvalbumin expression: cingulate and retrosplenial cortex.
MedLine Citation:
PMID:  17680608     Owner:  NLM     Status:  MEDLINE    
Age-dependent, MK801-induced, activated caspase-3 expression in the postnatal brain is generally not observed in neurons expressing calcium-binding proteins (CaBPs), suggesting that apoptosis and calcium buffering are inversely related. In regions such as the cingulate and retrosplenial cortex, injury peaks at postnatal Day 7 (P7) and rapidly diminishes thereafter, whereas expression of calbindin (CB) and calretinin (CR) was relatively low from P0 to P7 and steadily increased from P7 to P14. At ages thereafter, CB and CR expression either remained stable then declined or rapidly declined. Parvalbumin (PV) was generally low-absent prior to P7 but expression dramatically increased from P10 onwards, peaking at P21. These studies suggest calcium entry (through N-methyl-D-aspartate receptor (NMDARs)) and buffering (by CaBPs) are integral to normal CNS maturation. Because schizophrenia is associated with glutamate hypo-function, developmental injury, and aberrant CaBP expression, our data indicate that this postnatal brain injury model may offer important insights into the nature of this disorder.
Carla M Lema Tomé; Ryan Miller; Clayton Bauer; Charles Nottingham; Chelsey Smith; Kaitlin Blackstone; Lauren Brown; Rachael Bryan; Adam Leigh; Megan Brady; Jamie Busch; Christopher P Turner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental psychobiology     Volume:  49     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  606-18     Citation Subset:  IM    
Copyright Information:
Neurobiology & Anatomy, Wake Forest University Medical School, Medical Center Boulevard, Winston Salem, NC 27157-1010, USA.
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MeSH Terms
Age Factors
Brain Injuries / chemically induced*,  metabolism
Calcium / metabolism
Calcium-Binding Protein, Vitamin D-Dependent / metabolism
Caspase 3 / metabolism
Cell Count
Cerebral Cortex / drug effects*,  metabolism*
Dizocilpine Maleate / adverse effects*
Excitatory Amino Acid Antagonists / adverse effects*
Glutamic Acid / metabolism
Gyrus Cinguli / drug effects*,  metabolism*
Parvalbumins / antagonists & inhibitors*,  metabolism
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors,  metabolism
Grant Support
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Excitatory Amino Acid Antagonists; 0/Parvalbumins; 0/Receptors, N-Methyl-D-Aspartate; 0/calretinin; 56-86-0/Glutamic Acid; 7440-70-2/Calcium; 77086-22-7/Dizocilpine Maleate; EC 3.4.22.-/Caspase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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