| Decline in residual renal function in automated compared with continuous ambulatory peritoneal dialysis. | |
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MedLine Citation:
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PMID: 21393494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: We compared the decline of RRF in patients starting dialysis on APD with those starting on CAPD, because a faster decline on APD has been suggested. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: NECOSAD patients starting dialysis on APD or CAPD with RRF at baseline were included and followed for 3 years. Residual GFR (rGFR) was the mean of urea and creatinine clearances. Differences in yearly decline of rGFR were estimated in analyses with linear repeated measures models, whereas the risk of complete loss of RRF was estimated by calculating hazard ratios (HRs) for APD compared with CAPD. As-treated (AT) and intention-to-treat (ITT) designs were used. All of the analyses were adjusted for age, gender, comorbidity, and primary kidney disease and stratified according to follow-up and mean baseline GFR. RESULTS: The 505 CAPD and 78 APD patients had no major baseline differences. No differences were found in the analyses on yearly decline of rGFR. APD patients did have a higher risk of losing RRF in the first year (ITT crude HR 2.43 [confidence interval 95%, 1.48 to 4.00], adjusted 2.66 [1.60 to 4.44]; AT crude 1.89 [1.04 to 3.45], adjusted 2.15 [1.16 to 3.98]). The higher risk of losing all RRF was most pronounced in patients with the highest rGFR at baseline (ITT; crude 3.91 [1.54 to 9.94], adjusted 1.85 to 14.17). CONCLUSIONS: The risk of losing RRF is higher for patients starting dialysis on APD compared with those starting on CAPD, especially in the first year. |
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Authors:
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Wieneke Marleen Michels; Marion Verduijn; Diana C Grootendorst; Saskia le Cessie; Elisabeth Wilhelmina Boeschoten; Friedo Wilhelm Dekker; Raymond Theodorus Krediet; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2011-03-10 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 6 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-17 Completed Date: 2011-06-30 Revised Date: 2012-03-01 |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 537-42 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. w.m.michels@amc.uva.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Automation Chi-Square Distribution Female Glomerular Filtration Rate* Humans Kidney / physiopathology* Kidney Diseases / diagnosis, physiopathology, therapy* Linear Models Male Middle Aged Netherlands Peritoneal Dialysis / adverse effects, methods* Peritoneal Dialysis, Continuous Ambulatory* / adverse effects Risk Assessment Risk Factors Time Factors Treatment Outcome |
| Investigator | |
Investigator/Affiliation:
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A J Apperloo / ; J A Bijlsma / ; M Boekhout / ; W H Boer / ; P J M van der Boog / ; H R Büller / ; M van Buren / ; F T de Charro / ; C J Doorenbos / ; M A van den Dorpel / ; A van Es / ; W J Fagel / ; G W Feith / ; C W H de Fijter / ; L A M Frenken / ; W Grave / ; J A C A van Geelen / ; P G G Gerlag / ; J P M C Gorgels / ; R M Huisman / ; K J Jager / ; K Jie / ; W A H Koning-Mulder / ; M I Koolen / ; T K Kremer Hovinga / ; A T J Lavrijssen / ; A J Luik / ; J van der Meulen / ; K J Parlevliet / ; M H M Raasveld / ; F M van der Sande / ; M J M Schonck / ; M M J Schuurmans / ; C E H Siegert / ; C A Stegeman / ; P Stevens / ; J G P Thijssen / ; R M Valentijn / ; G H Vastenburg / ; C A Verburgh / ; H H Vincent / ; P F Vos / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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