Document Detail

Decline of hepatitis A antibodies during the first 7 months of life in full-term and preterm infants.
MedLine Citation:
PMID:  10219645     Owner:  NLM     Status:  MEDLINE    
In a previous study we have shown that transplacental transfer of hepatitis A antibodies to preterm infants does not differ from that observed in full-term infants. This follow-up study was designed to investigate the decline of hepatitis A virus (HAV) antibodies during the first 7 months of life in full-term and preterm infants, in an endemic region for hepatitis A. Two hundred and fifty newborn infants--147 full-term and 103 preterm infants--were enrolled. Blood samples from the infants were taken at birth, and at 3 and 7 months of age. Anti-HAV titers were determined by ELISA. A concentration of > or = 1:20 mlU/ml was considered protective. Protective hepatitis A antibodies were present at birth in 48.3% of all full-term and 49.5% of all premature infants. By the age of 7 months only 13% of full-term and 21.7% of preterm infants still had protective titers. For the seropositive full-term infants the geometric mean titers (GMT) were 15,698, 6,107 and 345 at birth, 3 months and 7 months, respectively, and for preterm infants, 10,378, 2,307 and 225 at birth, 3 months and 7 months, respectively. Significant differences in GMT between preterm and full-term infants were found at birth and at 3 months of age (P < 0.05). In a region endemic for hepatitis A, low levels of anti-HAV at 7 months of age may justify trials on infant vaccination since this is the most effective way to eliminate hepatitis A from circulation.
N Linder; Y Karetnyi; Y Gidony; R Dagan; G Ohel; E Levin; E Mendelson; A Barzilai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection     Volume:  27     ISSN:  0300-8126     ISO Abbreviation:  Infection     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-07-12     Completed Date:  1999-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365307     Medline TA:  Infection     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  128-31     Citation Subset:  IM    
Dept. of Neonatology, Schneider Children's Medical Center, Petach-Tikva, Israel.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Hepatitis A / blood,  immunology*
Hepatitis A Antibodies
Hepatitis Antibodies / blood*
Immunity, Maternally-Acquired*
Infant, Newborn
Infant, Premature / blood,  immunology*
Reg. No./Substance:
0/Hepatitis A Antibodies; 0/Hepatitis Antibodies

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