Document Detail

Decline of circadian photosensitivity associated with retinal degeneration in CBA/J-rd/rd mice.
MedLine Citation:
PMID:  9473668     Owner:  NLM     Status:  MEDLINE    
Although it is well known that visual image formation is mediated by rods and cones, photoreceptors implicated in entrainment of circadian rhythms remain unknown. In our previous study, 12-week-old CBA/J-rd/rd mice were found to show decreased sensitivity in circadian photoreception. Because rd gene induces different age-related degeneration of cones and rods, we have examined age-related changes in the sensitivity to a light pulse for phase-shifting the locomotor activity rhythms in CBA/J-rd/rd mice. Since mice have middlewave-sensitive cones (M-cone, 510 nm) and shortwave-sensitive cones (S-cone, 360 nm), a 15-min monochromatic light pulse (501.6 or 359 nm; 10 microW cm(-2) s(-1)) was given at circadian time (CT) 16, 2 weeks after being transferred to constant darkness (DD) and the magnitude of phase shift was determined. The amount of phase shift by a green light pulse (501.6 nm) gradually declined from 8 to 16 weeks after birth and the similar tendency was also observed on a UV pulse (359 nm). The similar pattern of age-related decline in the number of cones and circadian photosensitivity in CBA/J-rd/rd mice suggest that cones are involved in the circadian photoreception in mice.
T Yoshimura; S Ebihara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  779     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-02     Completed Date:  1998-04-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  188-93     Citation Subset:  IM    
Department of Animal Physiology, School of Agricultural Sciences, Nagoya University, Japan.
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MeSH Terms
Analysis of Variance
Circadian Rhythm / physiology*
Mice, Inbred CBA
Photoreceptor Cells / physiology*
Photosensitivity Disorders / physiopathology*
Retinal Degeneration / physiopathology*
Ultraviolet Rays

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