| Decitabine represses translocated MYC oncogene in Burkitt lymphoma. | |
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MedLine Citation:
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PMID: 23341364 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Burkitt lymphoma (BL) is caused by translocation of the MYC gene to an immunoglobulin locus resulting in its constitutive expression depending on the activity of the immunoglobulin (Ig) enhancer elements. Treatment of BL cell lines with epigenetic modifiers is known to repress B-cell specific genes and to up-regulate B-cell-inappropriate genes including the transcription repressor ID2 expression. We found that DNA methyltransferase inhibitor decitabine/5-aza-2-deoxycytidine (5-aza-dC) represses the MYC oncogene on RNA and protein levels by inducing ID2. Down-regulation of MYC was associated with repression of transcriptional activity of the Ig locus and with inhibition of proliferation. The induction of ID2 can be in part explained by activation of the transcription factor NF-κB. We conclude that up-regulation of ID2 contributes to antitumor activity of 5-aza-dC via repression of Ig locus activity and consequently MYC expression. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
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Authors:
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Hanfeng Guan; Linka Xie; Kay Klapproth; Clarissa D Weitzer; Thomas Wirth; Alexey Ushmorov |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-23 |
Journal Detail:
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Title: The Journal of pathology Volume: - ISSN: 1096-9896 ISO Abbreviation: J. Pathol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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