Document Detail

Decitabine (5-Aza-2'-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: preliminary observations.
MedLine Citation:
PMID:  9130689     Owner:  NLM     Status:  MEDLINE    
The authors report on the preliminary results of an ongoing phase II trial whereby the combination of the new DNA hypomethylating agent, 5-Aza-deoxycytidine (DAC), plus daunorubicin was given as first-line induction therapy to non-pretreated patients with acute myeloid leukemia (except FAB M3). DAC was given as a 4-h intravenous infusion at the dose of 90 mg/m2 daily from days 1-5, while daunorubicin was administered at the dose of 50 mg/m2 on days 1-3. A maximum of two courses were given to the patients with an interval of 4-6 weeks. Up to now, eight patients were accrued, of those six were evaluable for toxicity and response. The main toxic effects were bone marrow suppression, mucositis, nausea and vomiting, and alopecia. All six patients achieved a complete remission after one (five cases) or two (one case) courses. The trial is open for patient accrual.
G Schwartsmann; M S Fernandes; M D Schaan; M Moschen; L M Gerhardt; L Di Leone; B Loitzembauer; L Kalakun
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase II; Journal Article    
Journal Detail:
Title:  Leukemia     Volume:  11 Suppl 1     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S28-31     Citation Subset:  IM    
South-American Office for Anticancer Drug Development (SOAD), Hospital de Clinicas de Porto Alegre, RS, Brazil.
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MeSH Terms
Antimetabolites, Antineoplastic / administration & dosage,  therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / adverse effects,  therapeutic use*
Azacitidine / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Bone Marrow / drug effects,  pathology
Daunorubicin / administration & dosage
Drug Administration Schedule
Infusions, Intravenous
Leukemia, Myeloid, Acute / drug therapy*,  genetics,  immunology,  pathology
Middle Aged
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 20830-81-3/Daunorubicin; 320-67-2/Azacitidine; 776B62CQ27/decitabine

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