| Decision-making about genetic testing among women at familial risk for breast cancer. | |
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MedLine Citation:
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PMID: 9316177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Recent identification of the breast-ovarian cancer susceptibility gene BRCA1 and the breast cancer susceptibility gene BRCA2 have raised the possibility of clinical genetic testing for breast cancer susceptibility. This study examined decision-making about future susceptibility testing among women at familial risk for breast cancer. Based on the transtheoretical model, it was hypothesized that readiness to undergo testing would be related to the ratio between the perceived advantages (pros) and disadvantages (cons) of learning one's susceptibility status. METHODS: Seventy-four women with one or more first-degree relatives with breast cancer were recruited before a routine mammogram. Participants completed measures assessing readiness to undergo testing, perceived pros and cons of testing, and perceived breast cancer risk. Family history data was used to calculate empiric genetic risk of developing breast cancer. RESULTS: Forty-six per cent of participants planned to seek genetic testing as soon as possible, 35% planned to seek testing in the future, and 19% did not plan to seek testing. As expected, greater readiness to undergo testing was associated with a positive decisional balance (pros > cons). Older age and greater perceived risk (but not empiric risk) also were associated with greater readiness. CONCLUSION: The readiness of many women to seek breast cancer susceptibility testing can be attributed, in large part, to their perceptions that the advantages outweigh the disadvantages. Examination of these perceptions suggests that notification of carrier status may have significant effects on women's psychological well-being and breast cancer surveillance and prevention behaviors. |
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Authors:
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P B Jacobsen; H B Valdimarsdottier; K L Brown; K Offit |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Psychosomatic medicine Volume: 59 ISSN: 0033-3174 ISO Abbreviation: Psychosom Med Publication Date: 1997 Sep-Oct |
Date Detail:
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Created Date: 1997-12-19 Completed Date: 1997-12-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 459-66 Citation Subset: E; IM |
Affiliation:
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Department of Psychology, University of South Florida, Tampa 33620, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Attitude to Health* Breast Neoplasms / genetics, prevention & control*, psychology Chi-Square Distribution Cross-Sectional Studies Decision Making* Disease Susceptibility Family Health Female Genetic Testing / psychology* Humans Logistic Models Middle Aged Risk Assessment* Sampling Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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