Document Detail

Decision-making about genetic testing among women at familial risk for breast cancer.
MedLine Citation:
PMID:  9316177     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recent identification of the breast-ovarian cancer susceptibility gene BRCA1 and the breast cancer susceptibility gene BRCA2 have raised the possibility of clinical genetic testing for breast cancer susceptibility. This study examined decision-making about future susceptibility testing among women at familial risk for breast cancer. Based on the transtheoretical model, it was hypothesized that readiness to undergo testing would be related to the ratio between the perceived advantages (pros) and disadvantages (cons) of learning one's susceptibility status. METHODS: Seventy-four women with one or more first-degree relatives with breast cancer were recruited before a routine mammogram. Participants completed measures assessing readiness to undergo testing, perceived pros and cons of testing, and perceived breast cancer risk. Family history data was used to calculate empiric genetic risk of developing breast cancer. RESULTS: Forty-six per cent of participants planned to seek genetic testing as soon as possible, 35% planned to seek testing in the future, and 19% did not plan to seek testing. As expected, greater readiness to undergo testing was associated with a positive decisional balance (pros > cons). Older age and greater perceived risk (but not empiric risk) also were associated with greater readiness. CONCLUSION: The readiness of many women to seek breast cancer susceptibility testing can be attributed, in large part, to their perceptions that the advantages outweigh the disadvantages. Examination of these perceptions suggests that notification of carrier status may have significant effects on women's psychological well-being and breast cancer surveillance and prevention behaviors.
P B Jacobsen; H B Valdimarsdottier; K L Brown; K Offit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Psychosomatic medicine     Volume:  59     ISSN:  0033-3174     ISO Abbreviation:  Psychosom Med     Publication Date:    1997 Sep-Oct
Date Detail:
Created Date:  1997-12-19     Completed Date:  1997-12-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  459-66     Citation Subset:  E; IM    
Department of Psychology, University of South Florida, Tampa 33620, USA.
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MeSH Terms
Analysis of Variance
Attitude to Health*
Breast Neoplasms / genetics,  prevention & control*,  psychology
Chi-Square Distribution
Cross-Sectional Studies
Decision Making*
Disease Susceptibility
Family Health
Genetic Testing / psychology*
Logistic Models
Middle Aged
Risk Assessment*
Sampling Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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