Document Detail

Deciphering the fluorescent variability of human genomic heterochromatin by DA/DAPI technique.
MedLine Citation:
PMID:  1283119     Owner:  NLM     Status:  MEDLINE    
A number of selective staining techniques have been utilized to decipher the variability of pericentromeric heterochromatin. One such technique is called DA/DAPI and it is believed to be stain specific. However, we demonstrate otherwise and suggest that pericentromeric regions of all human chromosomes stain positive by DA/DAPI-technique. It must be emphasized that the incidence of DA/DAPI positive stained chromosomes, other than 1, 9, 15, 16 and Y, is a rare occurrence and only a small portion of the pericentromeric region is DA/DAPI positive, as reported here using 50 normal individuals.
R S Verma; R A Conte; S Luke; V Sindwani; M J Macera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical genetics     Volume:  42     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  267-70     Citation Subset:  IM    
Division of Genetics, Long Island College Hospital, N.Y. 11201.
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MeSH Terms
Fluorescent Dyes*
Staining and Labeling / methods*
Reg. No./Substance:
0/Distamycins; 0/Fluorescent Dyes; 0/Heterochromatin; 0/Indoles; 47165-04-8/DAPI; 636-47-5/stallimycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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