Document Detail

Deciphering Arrhythmia Mechanisms - Tools of the Trade.
MedLine Citation:
PMID:  21572551     Owner:  NLM     Status:  Publisher    
Pathophysiological remodeling of cardiac function occurs at multiple levels, spanning the spectrum from molecular and sub-cellular changes to those occurring at the organ-system levels. Of key importance to arrhythmias are changes in electrophysiological and calcium handling properties at the tissue level. In this review, we discuss how high-resolution optical action potential and calcium transient imaging has advanced our understanding of basic arrhythmia mechanisms associated with multiple cardiovascular disorders, including the long QT syndrome, heart failure, and ischemia-reperfusion injury. We focus on the role of repolarization gradients (section 1) and calcium mediated triggers (section 2) in the initiation and maintenance of complex arrhythmias in these settings.
Guy Salama; Fadi G Akar
Publication Detail:
Journal Detail:
Title:  Cardiac electrophysiology clinics     Volume:  3     ISSN:  1877-9190     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101549998     Medline TA:  Card Electrophysiol Clin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  11-21     Citation Subset:  -    
University of Pittsburgh, The Cardiovascular Institute, Pittsburgh, PA, 15261.
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Grant Support
R01 HL057929-08//NHLBI NIH HHS; R01 HL057929-09//NHLBI NIH HHS; R01 HL059614-04//NHLBI NIH HHS; R01 HL093074-01A2//NHLBI NIH HHS; R01 HL093074-02//NHLBI NIH HHS; R01 HL093074-03//NHLBI NIH HHS

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