Document Detail


Deciphering Arrhythmia Mechanisms - Tools of the Trade.
MedLine Citation:
PMID:  21572551     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pathophysiological remodeling of cardiac function occurs at multiple levels, spanning the spectrum from molecular and sub-cellular changes to those occurring at the organ-system levels. Of key importance to arrhythmias are changes in electrophysiological and calcium handling properties at the tissue level. In this review, we discuss how high-resolution optical action potential and calcium transient imaging has advanced our understanding of basic arrhythmia mechanisms associated with multiple cardiovascular disorders, including the long QT syndrome, heart failure, and ischemia-reperfusion injury. We focus on the role of repolarization gradients (section 1) and calcium mediated triggers (section 2) in the initiation and maintenance of complex arrhythmias in these settings.
Authors:
Guy Salama; Fadi G Akar
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Cardiac electrophysiology clinics     Volume:  3     ISSN:  1877-9190     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101549998     Medline TA:  Card Electrophysiol Clin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  11-21     Citation Subset:  -    
Affiliation:
University of Pittsburgh, The Cardiovascular Institute, Pittsburgh, PA, 15261.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 HL057929-08//NHLBI NIH HHS; R01 HL057929-09//NHLBI NIH HHS; R01 HL059614-04//NHLBI NIH HHS; R01 HL093074-01A2//NHLBI NIH HHS; R01 HL093074-02//NHLBI NIH HHS; R01 HL093074-03//NHLBI NIH HHS

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