Document Detail


Decay and persistence of maternal dengue antibodies among infants in Bangkok.
MedLine Citation:
PMID:  21813859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abstract. Maternal dengue antibodies are important in determining the optimal age of dengue vaccination, but no study has quantified the heterogeneity of antibody decay and persistence in infants. We used longitudinal regression methods and survival analysis to measure decay and persistence times of serotype-specific neutralizing antibodies in 139 infants in Bangkok. A biphasic decay pattern was found with half-life times of 24-29 days between birth and 3 months and 44-150 days after 3 months. Atypical decay rates were found in 17% of infants for dengue virus-1 and -4. Median persistence times of plaque reduction neutralization tests > 10 ranged from 6 to 9 months. Persistence times for individuals could not be predicted based on antibody values at birth. Vaccination against dengue before 12 months of age would be ineffective if maternal antibodies at plaque reduction neutralization test levels below 80 interfere with vaccine uptake. Projections of average antibody persistence based on values at birth should be avoided in studies on dengue pathogenesis in infants.
Authors:
Willem G van Panhuis; Christine Luxemburger; Krisana Pengsaa; Kriengsak Limkittikul; Arunee Sabchareon; Jean Lang; Anna P Durbin; Derek A T Cummings
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  85     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-04     Completed Date:  2011-10-04     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  355-62     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / blood*
Cohort Studies
Dengue / immunology*
Dengue Virus / classification,  immunology*
Humans
Immunity, Maternally-Acquired*
Infant
Infant, Newborn
Thailand / epidemiology
Time Factors
Grant Support
ID/Acronym/Agency:
R01 TW008246/TW/FIC NIH HHS; U54 GM088491/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral
Comments/Corrections

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