Document Detail

Decarboxylation of exogenous L-3,4-dihydroxyphenylalanine in rat striatum as studied by in vivo voltammetry.
MedLine Citation:
PMID:  1727424     Owner:  NLM     Status:  MEDLINE    
An in vivo voltammetric technique was used to determine whether striatal nondopaminergic neurons take up and decarboxylate exogenous L-3,4-dihydroxyphenylalanine (L-DOPA) and release it as dopamine. After the striatal serotonergic neurons of the rat had been destroyed by intraventricular injection of 5,7-dihydroxytryptamine, L-DOPA was administered intraperitoneally. It was found that changes in the dopamine concentration in the striatal extracellular fluid of the rat were the same as those in the nonlesioned rat. L-DOPA was also administered to the rat after the striatal perikarya had been destroyed by the intrastriatal injection of kainate. The striatal dopamine concentrations of the lesioned rat changed in parallel with 5,7-dihydroxytryptamine-lesioned rats, as well as the nonlesioned rats. Moreover, when normal rats were administered L-DOPA, the dopamine concentration was not increased in the cerebellum, where dopamine neurons do not exist. From these observations, it is concluded that exogenous L-DOPA is taken up, decarboxylated to dopamine, and released only in the striatal dopamine neurons.
T Nakazato; A Akiyama
Related Documents :
2576744 - Effect of adafenoxate on different rat brain structures monoamine oxidase activity in v...
24073314 - The effect of cochinchina momordica seed extract on gastric acid secretion and morpholo...
9519684 - Preparation and pharmacological evaluation of physostigmine-loaded polyisobutylcyanoacr...
3363224 - Inhibition of the rat hepatic mixed-function oxidases by in vivo administration of clot...
3047124 - Studies with antipeptide antibody suggest the presence of at least two types of glucose...
197774 - Radiation-induced nerve root degeneration and hypertrophic neuropathy in the lumbosacra...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  58     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-01-22     Completed Date:  1992-01-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Department of Physiology, Juntendo University School of Medicine, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
5,7-Dihydroxytryptamine / pharmacology
Cerebellum / metabolism
Corpus Striatum / drug effects,  metabolism*,  pathology
Electrochemistry / methods
Electrodes, Implanted
Levodopa / metabolism*
Rats, Inbred Strains
Reg. No./Substance:
0/Levodopa; 31363-74-3/5,7-Dihydroxytryptamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Determination of acidic metabolites of biogenic amines in human aqueous humour by gas chromatography...
Next Document:  Developmental and age-dependent changes of 28-kDa calbindin-D in the central nervous tissue determin...