| Decarboxylation of 2-keto fatty acids by brain. | |
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MedLine Citation:
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PMID: 4287768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An enzyme system consisting of washed acetone powder of pig brain, adenosine triphosphate, nicotinamide adenine dinucleotide, magnesium, fumaric acid, and ascorbic acid was found to catalyze the oxidative decarboxylation of 2-ketostearic acid. The products were carbon dioxide and heptadecanoic acid. Washing the enzyme powder with ethylene-diaminetetraacetate and other chelating agents destroyed the activity. Further properties of the enzyme system are described. It is believed that this enzyme system accounts in part for the 1-carbon degradation route for brain fatty acids. |
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Authors:
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W E Davies; A K Hajra; S S Parmar; N S Radin; J F Mead |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of lipid research Volume: 7 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1966 Mar |
Date Detail:
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Created Date: 1966-10-19 Completed Date: 1966-10-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 270-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Ascorbic Acid / metabolism Brain / enzymology*, metabolism* Carboxy-Lyases / metabolism* Fatty Acids / metabolism* Fumarates / metabolism Iron / metabolism Keto Acids / metabolism* Magnesium / metabolism NAD / metabolism Stearic Acids / metabolism* Subcellular Fractions / metabolism Swine |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fumarates; 0/Keto Acids; 0/Stearic Acids; 50-81-7/Ascorbic Acid; 53-84-9/NAD; 56-65-5/Adenosine Triphosphate; 7439-89-6/Iron; 7439-95-4/Magnesium; EC 4.1.1.-/Carboxy-Lyases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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