| Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells. | |
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MedLine Citation:
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PMID: 20940725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Osteoblasts are the cells responsible for bone formation during embryonic development and adult life. Small compounds that could induce osteoblast differentiation might be promising sources of therapies for bone diseases such as osteoporosis. During screening for inducers of osteoblast differentiation of mouse pluripotent mesenchymal C3H10T1/2 cells, we isolated a small compound from the fermentation broth of Penicillium verruculosum CR37010. This compound, named decalpenic acid, bears a decalin moiety with a tetraenoic acid side chain. Treatment of C3H10T1/2 cells with decalpenic acid alone induced the expression of early osteoblast markers, such as alkaline phosphatase activity and osteopontin mRNA, but did not induce the late osteoblast marker osteocalcin mRNA or adipocyte markers under our experimental conditions. |
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Authors:
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Shuichi Sakamoto; Fukiko Kojima; Masayuki Igarashi; Ryuichi Sawa; Maya Umekita; Yumiko Kubota; Koichi Nakae; Shoichi Yamaguchi; Hayamitsu Adachi; Yoshio Nishimura; Yuzuru Akamatsu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-13 |
Journal Detail:
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Title: The Journal of antibiotics Volume: 63 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-23 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 703-8 Citation Subset: IM |
Affiliation:
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Institute of Microbial Chemistry, Shinagawa-ku, Tokyo, Japan. sakamotos@bikaken.or.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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genetics,
metabolism Animals Carboxylic Acids / chemistry, isolation & purification*, pharmacology Cell Differentiation / drug effects Cell Line DNA / chemistry, genetics Macrolides / chemistry, isolation & purification*, pharmacology Mesenchymal Stem Cells / cytology, drug effects*, metabolism Mice Molecular Structure Nuclear Magnetic Resonance, Biomolecular Osteoblasts / cytology, drug effects*, metabolism Penicillium / chemistry* Pluripotent Stem Cells / cytology, drug effects*, metabolism Polymerase Chain Reaction Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
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0/Carboxylic Acids; 0/Macrolides; 9007-49-2/DNA; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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