Document Detail

Decalcifying effect of 15% EDTA, 15% citric acid, 5% phosphoric acid and 2.5% sodium hypochlorite on root canal dentine.
MedLine Citation:
PMID:  18298573     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate and compare ex vivo the decalcifying effect of 15% EDTA, 15% citric acid, 5% phosphoric acid and 2.5% sodium hypochlorite on root canal dentine. METHODOLOGY: Two 2-mm-thick slices were cut from the coronal third of the root of 10 human incisors. Each slice was sectioned into two equal parts. Specimens were assigned to one of four groups (n = 10) for immersion in 20 mL of either 15% EDTA, or 15% citric acid, 5% phosphoric acid or 2.5% NaOCl, for three time periods (5, 10 and 15 min). The concentration of Ca(2+) extracted from the dentine was measured by atomic absorption spectrophometry. The amount of calcium extracted was analysed using the Kruskal-Wallis test for global comparisons and the Mann-Whitney U-test for pairwise comparisons. RESULTS: In the three time periods, 15% EDTA and 15% citric acid extracted the largest amount of calcium, with no significant differences between them. The 2.5% NaOCl solution extracted insignificant amounts of calcium, whereas 15% EDTA extracted 86.72% of the calcium in the first 5 min, and 15% citric acid and 5% phosphoric acid had a similar pattern of calcium removal (77.03% and 67.08% in first 5 min, respectively). CONCLUSIONS: Solutions of 15% EDTA, 15% citric acid and 5% phosphoric acid decalcify root dentine, with most calcium extracted during the first 5 min of action. The efficacy of 15% citric acid and 15% EDTA solutions was significantly greater than that of 5% phosphoric acid solution at each time period (5, 10 and 15 min).
M Pérez-Heredia; C M Ferrer-Luque; M P González-Rodríguez; F J Martín-Peinado; S González-López
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Publication Detail:
Type:  Journal Article     Date:  2008-02-20
Journal Detail:
Title:  International endodontic journal     Volume:  41     ISSN:  1365-2591     ISO Abbreviation:  Int Endod J     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-11     Completed Date:  2008-05-19     Revised Date:  2008-08-07    
Medline Journal Info:
Nlm Unique ID:  8004996     Medline TA:  Int Endod J     Country:  England    
Other Details:
Languages:  eng     Pagination:  418-23     Citation Subset:  D    
Department of Dental Pathology and Therapeutics, School of Dentistry, University of Granada, Spain.
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MeSH Terms
Calcium / analysis
Citric Acid / pharmacology
Decalcification Technique
Dental Pulp Cavity
Dentin / chemistry*,  drug effects*
Edetic Acid / pharmacology
Middle Aged
Phosphoric Acids / pharmacology
Regression Analysis
Root Canal Irrigants / pharmacology*
Smear Layer
Sodium Hypochlorite / pharmacology
Spectrophotometry, Atomic
Statistics, Nonparametric
Reg. No./Substance:
0/Phosphoric Acids; 0/Root Canal Irrigants; 60-00-4/Edetic Acid; 7440-70-2/Calcium; 7664-38-2/phosphoric acid; 7681-52-9/Sodium Hypochlorite; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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