Document Detail


Decacationic [70]Fullerene Approach for Efficient Photokilling of Infectious Bacteria and Cancer Cells.
MedLine Citation:
PMID:  24396566     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Photodynamic inactivation of pathogenic bacteria and cancer cells by novel water-soluble decacationic fullerene monoadducts, C60[>M(C3N6 (+)C3)2] and C70[>M(C3N6 (+)C3)2], were investigated. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[>M(C3N6 (+)C3)2] produced more highly reactive HO(•) radical than C60[>M(C3N6 (+)C3)2], in addition to singlet oxygen ((1)O2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C3N6 (+)C3)2] and C70[>M(C3N6 (+)C3)2], respectively. The hypothesis is that (1)O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO(•) to cause real damage.
Authors:
L Huang; M Wang; S K Sharma; F F Sperandio; S Maragani; S Nayka; J Chang; M R Hamblin; L Y Chiang
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  ECS transactions     Volume:  45     ISSN:  1938-5862     ISO Abbreviation:  ECS Trans     Publication Date:  2013  
Date Detail:
Created Date:  2014-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101617957     Medline TA:  ECS Trans     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 CA137108/CA/NCI NIH HHS

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