Document Detail

Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure.
MedLine Citation:
PMID:  14740725     Owner:  NLM     Status:  MEDLINE    
The congener 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE 209) is the primary component in a commonly used flame retardant known as decaBDE. This flame retardant constitutes approximately 80% of the world market demand for polybrominated diphenyl ethers (PBDEs). Because this compound is very hydrophobic (log K(ow) approximately 10), it has been suggested that BDE 209 has very low bioavailability, although debromination to more bioavailable metabolites has also been suggested to occur in fish tissues. In the present study, juvenile carp were exposed to BDE 209 amended food on a daily basis for 60 days, followed by a 40-day depuration period in which the fate of BDE 209 was monitored in whole fish and liver tissues separately. No net accumulation of BDE 209 was observed throughout the experiment despite an exposure concentration of 940 ng/day/fish. However, seven apparent debrominated products of BDE 209 accumulated in whole fish and liver tissues over the exposure period. These debrominated metabolites of BDE 209 were identified as penta- to octaBDEs using both GC/ECNI-MS and GC/HRMS. Using estimation methods for relative retention times of phenyl substitution patterns, we have identified possible structures for the hexa- and heptabromodiphenyl ethers identified in the carp tissues. Although exposure of carp to BDE 209 did not result in the accumulation of BDE 209 in carp tissues, our results indicate evidence of limited BDE 209 bioavailability from food in the form of lower brominated metabolites.
Heather M Stapleton; Mehran Alaee; Robert J Letcher; Joel E Baker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental science & technology     Volume:  38     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-03-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-9     Citation Subset:  IM    
Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA.
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MeSH Terms
Administration, Oral
Biological Availability
Bromobenzenes / metabolism*,  pharmacokinetics
Carps / physiology*
Dose-Response Relationship, Drug
Flame Retardants / metabolism*,  pharmacokinetics
Halogenated Diphenyl Ethers
Liver / chemistry
Phenyl Ethers
Polybrominated Biphenyls
Tissue Distribution
Water Pollutants, Chemical / metabolism*,  pharmacokinetics
Reg. No./Substance:
0/Bromobenzenes; 0/Flame Retardants; 0/Halogenated Diphenyl Ethers; 0/Phenyl Ethers; 0/Polybrominated Biphenyls; 0/Water Pollutants, Chemical; 1163-19-5/decabromobiphenyl ether
Comment In:
Environ Sci Technol. 2004 Jan 1;38(1):8A-9A   [PMID:  14740707 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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