| Deaths involving serotonergic drugs. | |
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MedLine Citation:
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PMID: 20172668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serotonin-active drugs are detected relatively frequently in Victorian deaths. During 2002-2008, there were 1123 fatalities where one or more of the serotonin-active drugs tramadol, venlafaxine, fluoxetine, sertraline, citalopram, paroxetine and MDMA, were detected. These deaths were reviewed using pathology, toxicology and police reports, to determine the contribution of these drugs to the cause of death, particularly if serotonin toxicity was the mechanism of death. There were 28 cases of most interest to this research because of the presence of the target drugs and the circumstances suggesting the likelihood of serotonin toxicity involvement in death. There were 5 cases of reported serotonin toxicity and 23 other deaths suspected to have involved this form of toxicity. Tramadol featured most commonly out of the seven target drugs and was frequently detected in combination with serotonergic antidepressants. MDMA was also detected relatively commonly and was associated with moclobemide in 4 cases of confirmed serotonin toxicity. There were an additional 1095 cases where natural disease, external injury or the misuse of other drugs caused death, of which 2 reported the incidental contribution of serotonin toxicity. |
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Authors:
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J L Pilgrim; D Gerostamoulos; Olaf H Drummer |
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Publication Detail:
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Type: Journal Article Date: 2010-02-20 |
Journal Detail:
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Title: Forensic science international Volume: 198 ISSN: 1872-6283 ISO Abbreviation: Forensic Sci. Int. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-08-18 Revised Date: 2011-05-11 |
Medline Journal Info:
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Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: Ireland |
Other Details:
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Languages: eng Pagination: 110-7 Citation Subset: IM |
Affiliation:
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Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Australia Cause of Death Citalopram / adverse effects, blood Cyclohexanols / adverse effects, blood Female Fluoxetine / adverse effects, blood Forensic Toxicology Gas Chromatography-Mass Spectrometry Humans Male Middle Aged N-Methyl-3,4-methylenedioxyamphetamine / adverse effects, blood Paroxetine / adverse effects, blood Serotonin Agents / adverse effects*, blood Sertraline / adverse effects, blood Tramadol / adverse effects, blood |
| Chemical | |
Reg. No./Substance:
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0/Cyclohexanols; 0/Serotonin Agents; 27203-92-5/Tramadol; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine; 54910-89-3/Fluoxetine; 59729-33-8/Citalopram; 61869-08-7/Paroxetine; 79617-96-2/Sertraline; 93413-69-5/venlafaxine |
| Comments/Corrections | |
Comment In:
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Forensic Sci Int. 2011 Apr 15;207(1-3):e62
[PMID:
21183298
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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