| Death and replacement of uterine epithelial cells during oil-induced deciduoma development in the mouse. | |
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MedLine Citation:
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PMID: 8742697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A decidual cell reaction can be induced in rodent endometrium by an intrauterine injection of oil. The epithelial lining is thought to be instrumental to transduce intralumenal stimuli for decidualization. One of the consequences of oil injection is the death of uterine epithelial cells. No information is available on the effect that sustained contact with oil has on the epithelium. METHODS: A decidual cell reaction was induced in 4-day pseudopregnant mice by injection of 30 microliters of arachis oil into the uterine lumen. Samples from the uteri were collected 24, 48, and 72 h after the injection and prepared for transmission electron microscopy. RESULTS: Twenty-four hours after the oil injection, some of the initial modifications of epithelial cell surfaces were very similar to those induced by the contact with the blastocyst during normal pregnancy. Uterine epithelial cells internalized injected oil and many cells were seen in various stages of degeneration. At 48 h, many epithelial cells were detached from the basal lamina. At 72 h, the uterine lining was re-established by flattened cells. CONCLUSIONS: The contact of oil with the uterine epithelium of pseudo pregnant mice induces epithelial cell death in the antimesometrial region of the uterine crypt. There is, however, replacement of epithelial lining by epithelial cells, which probably migrate from the mesometrial region of the crypt. The prolonged presence of oil within the uterine lumen seems to induce cycles of epithelial cell death and replacement. |
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Authors:
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C G Andrade; P A Abrahamsohn; F Godinho; E Samuel; T M Zorn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Anatomical record Volume: 244 ISSN: 0003-276X ISO Abbreviation: Anat. Rec. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-10-21 Completed Date: 1996-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370540 Medline TA: Anat Rec Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 316-26 Citation Subset: IM |
Affiliation:
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Department of Histology and Embryology, University of São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Death Cell Division Decidua / growth & development* Endometrium / cytology* Female Mice Microscopy, Electron Plant Oils / administration & dosage Pregnancy Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Plant Oils; 8002-03-7/arachis oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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