Document Detail


Death related to albendazole-induced pancytopenia: case report and review.
MedLine Citation:
PMID:  15772324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Albendazole is a benzimidazole with wide spectrum coverage as an antiparasitic drug. Reported side effects have been minimal. We report the case of a patient who died with severe prolonged pancytopenia beginning during the third week of therapy for a pulmonary echinococcal cyst. This case was a 68-year-old man who presented with a large cystic lung mass. His medical history was significant for Child-Pugh class B cirrhosis. A prolonged course of albendazole was initiated. Two weeks later, the patient presented in septic shock with severe pancytopenia. The patient was initially resuscitated, but died after 10 days with no marrow recovery. Autopsy was consistent with albendazole-induced pancytopenia. This is the third human case of pancytopenia and the first death reported in relation to albendazole-induced pancytopenia. Neutropenia seems to be related more to higher dosage and longer duration of use. Albendazole sulfoxide peak dose and half life are significantly prolonged by liver disease and concomitant administration of certain drugs. The severity and duration of albendazole-induced pancytopenia in this case was likely related to the underlying liver disease. Frequent serial monitoring of blood counts and cessation of medication with any evidence of marrow toxicity in such patients is warranted.
Authors:
Lucie Opatrny; Roger Prichard; Linda Snell; J Dick Maclean
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  72     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-17     Completed Date:  2005-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-4     Citation Subset:  AIM; IM    
Affiliation:
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Hospital Center, Montreal, Quebec, Canada. lucie.opatrny@muhc.mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Aged
Albendazole / adverse effects*
Anthelmintics / adverse effects*
Autopsy
Biopsy
Echinococcosis / drug therapy*
Esophageal and Gastric Varices / parasitology
Fatal Outcome
Humans
Liver Cirrhosis / parasitology,  pathology
Male
Pancytopenia / chemically induced*
Chemical
Reg. No./Substance:
0/Anthelmintics; 54965-21-8/Albendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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