Document Detail


Death and inflammation following somatic cell transplantation.
MedLine Citation:
PMID:  21533908     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The fields of regenerative medicine and cellular therapy have been the subject of tremendous hype and hope. In particular, the perceived usage of somatic cells like mesenchymal stromal stem cells (MSCs) has captured the imagination of many. Clinical trials are currently evaluating the therapeutic efficacy of MSCs in disorders ranging from heart disease to pediatric graft-vs-host disease; however, numerous questions still remain regarding mechanism of action, effective dose, and whether these cells can be used in the allogeneic setting. One of the major issues surrounding the development of somatic cell therapies like MSCs is that despite evoking a positive response, long-term engraftment and persistence of these cells is rare. Consequently, very large cell doses need be administered raising production, delivery, and efficacy issues. In this review, we will discuss causes for this lack of persistence and highlight some of the methodologies be used to enhance cell survival post-transplantation.
Authors:
Ian B Copland; Jacques Galipeau
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-1
Journal Detail:
Title:  Seminars in immunopathology     Volume:  -     ISSN:  1863-2300     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308769     Medline TA:  Semin Immunopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA, ian.copland@emory.edu.
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