Document Detail

Death from a morphine infusion during a sickle cell crisis.
MedLine Citation:
PMID:  8345436     Owner:  NLM     Status:  MEDLINE    
A 15-year-old boy died during a vaso-occlusive sickle cell crisis after having received a prolonged infusion of morphine. Even in therapeutic doses, narcotics may cause significant respiratory acidosis and hypoxemia, enhancing polymerization of hemoglobin SS and thereby promoting sickling and vaso-occlusion. When narcotics are used during a sickle cell crisis, the best method is pharmacokinetically based patient-controlled analgesia.
N Gerber; G Apseloff
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  123     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-09     Completed Date:  1993-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  322-5     Citation Subset:  AIM; IM    
Department of Pharmacology, Ohio State University College of Medicine, Columbus 43210-1239.
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MeSH Terms
Anemia, Sickle Cell / complications*
Death, Sudden, Cardiac / etiology*
Infusions, Intravenous
Morphine / adverse effects*,  therapeutic use
Pain / drug therapy,  etiology*
Respiratory Insufficiency / chemically induced*
Reg. No./Substance:
Comment In:
J Pediatr. 1994 Jul;125(1):175-6   [PMID:  8021778 ]
J Pediatr. 1994 Jan;124(1):162-3   [PMID:  8283370 ]

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