| Death of a female cocaine user due to the serotonin syndrome following moclobemide-venlafaxine overdose. | |
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MedLine Citation:
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PMID: 19131198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To our knowledge, the majority of evidence supporting the relationship between the serotonin syndrome and medications that effect 5HT is based on case reports. The justification for taking up this subject has been a fatal outcome of a 21 year-old female following an administration of toxic doses of moclobemide (MAOI) and venlafaxine (SNRI). As a result of complex toxicological investigations including antemortem and postmortem material, antemortem clinical observations and postmortem examinations, the cause of death was identified as overdose with antidepressants--moclobemide and venlafaxine--in the mechanism of the clinically fully developed severe toxic serotonin syndrome. The analysis of a hair strand collected from the victim documented the use of the above-mentioned drugs simultaneously with cocaine in the period of at least 20 months preceding death. The fact is a matter of considerable interest in view of the employed pharmacotherapy, giving rise to suspicion that the woman had not developed the serotonin syndrome during the almost 2-year antemortem period until she took toxic doses of both medications. |
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Authors:
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Małgorzata Kłys; Piotr Kowalski; Sebastian Rojek; Adam Gross |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-01-07 |
Journal Detail:
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Title: Forensic science international Volume: 184 ISSN: 1872-6283 ISO Abbreviation: Forensic Sci. Int. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-06-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: Ireland |
Other Details:
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Languages: eng Pagination: e16-20 Citation Subset: IM |
Affiliation:
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Institute of Forensic Medicine Jagiellonian University Collegium Medicum, Toxicology Department, Grzegorzecka St. 16, 31-531 Krakow, Poland. mpklys@cyf-kr.edu.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cocaine
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analysis Cocaine-Related Disorders / complications* Cyclohexanols / analysis, poisoning* Dopamine Uptake Inhibitors / analysis Female Forensic Toxicology Hair / chemistry Humans Moclobemide / analysis, poisoning* Monoamine Oxidase Inhibitors / analysis, poisoning* Overdose Serotonin Syndrome / chemically induced* Serotonin Uptake Inhibitors / analysis, poisoning* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cyclohexanols; 0/Dopamine Uptake Inhibitors; 0/Monoamine Oxidase Inhibitors; 0/Serotonin Uptake Inhibitors; 50-36-2/Cocaine; 71320-77-9/Moclobemide; 93413-69-5/venlafaxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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