Document Detail


Death and anti-death: tumour resistance to apoptosis.
MedLine Citation:
PMID:  12001989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells often have faulty apoptotic pathways. These defects not only increase tumour mass, but also render the tumour resistant to therapy. So, what are the molecular mechanisms of tumour resistance to apoptosis and how can we use this knowledge to resensitize tumour cells to cancer therapy?
Authors:
Frederik H Igney; Peter H Krammer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature reviews. Cancer     Volume:  2     ISSN:  1474-175X     ISO Abbreviation:  Nat. Rev. Cancer     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-10     Completed Date:  2002-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101124168     Medline TA:  Nat Rev Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  277-88     Citation Subset:  IM    
Affiliation:
Tumor Immunology Program, German Cancer Research Center (DKFZ), Heidelberg.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Down-Regulation
Humans
Ligands
Mitochondria / metabolism
Models, Biological
Neoplasms / pathology*
Proto-Oncogene Proteins c-bcl-2 / metabolism
Signal Transduction
Tumor Suppressor Protein p53 / metabolism
Chemical
Reg. No./Substance:
0/Ligands; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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