| Death caused by toxic epidermal necrolysis (Lyell syndrome). | |
| | |
MedLine Citation:
|
PMID: 20345799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Toxic epidermal necrolysis (TEN) is characterized by fever, scalded appearance of the skin, and epidermolysis associated to blister formation and exfoliation, and it is caused by hypersensitivity reaction to a drug. The authors report two cases of death as a result of TEN; both referred to old aged women treated with a polytherapy including allopurinol. Both patients displayed erythematous skin lesions similar to scald burns and epidermolysis at the face, chest, and abdomen and died shortly after hospitalization. Autopsy findings and histological examinations revealed epidermal necrolysis and confirmed the clinical diagnosis. A strict time-correlation between allopurinol administration and symptoms was evidenced. Because of its iatrogenic origin, TEN often arises suspicions of medical liability; however, because of its unpredictable nature, the occurrence of this syndrome cannot be ascribed to the medical staff whose main task is the rapid diagnosis and the correct management. |
| | |
Authors:
|
Francesco Ventura; Tony Fracasso; Andrea Leoncini; Raffaella Gentile; Francesco de Stefano |
Related Documents
:
|
14726889 - Intravenous immunoglobulin prophylaxis for recurrent stevens-johnson syndrome. 15663299 - Clophen a60 composition and content of cbs, cns, cdfs, and cdds after 2d-hplc, hrgc/lrm... 17159439 - Update on toxic anterior segment syndrome. 19874369 - Nonpigmenting fixed drug eruption as a possible abortive variant of toxic epidermal nec... 3256819 - Scarlet fever can mimic toxic shock syndrome. 9433029 - Stevens-johnson syndrome and toxic epidermal necrolysis are severity variants of the sa... 1756519 - Severe hyperlipidemia due to multiple factors in a child with nephrotic syndrome. 16295449 - Meckel gruber syndrome--a case report. 16430529 - Dental findings of a child with wolf-hirschhorn syndrome. |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2010-03-15 |
Journal Detail:
|
Title: Journal of forensic sciences Volume: 55 ISSN: 1556-4029 ISO Abbreviation: J. Forensic Sci. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-06-10 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375370 Medline TA: J Forensic Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 839-41 Citation Subset: IM |
Affiliation:
|
Department of Legal Medicine, University of Genova, via De' Toni 12, 16132 Genova, Italy. francesco.ventura@unige.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Allopurinol / adverse effects Epidermal Necrolysis, Toxic / diagnosis, pathology* Fatal Outcome Female Gout Suppressants / adverse effects Humans Multiple Organ Failure / etiology |
| Chemical | |
Reg. No./Substance:
|
0/Gout Suppressants; 315-30-0/Allopurinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heteroplasmy in Hair: Study of Mitochondrial DNA Third Hypervariable Region in Hair and Blood Sample...
Next Document: Reconstruction of Deformed Bite Marks Using Affine Transformations.