| Deamination of 2-propyl-1-aminopentane and 2-[(2-propyl)pentylamino] acetamide by amine oxidases: formation of valproic acid. | |
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MedLine Citation:
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PMID: 1908106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. 2-Propyl-1-aminopentane and 2-[(2-propyl)pentylamino]acetamide are deaminated by rat liver monoamine oxidase (MAO) and aorta semicarbazide-sensitive amine oxidase (SSAO). 2. The deaminated product, 2-propylpentaldehyde, is further converted to valproic acid in vitro as well as in vivo. 3. The anticonvulsant action of these two compounds could not be substantiated, because both drugs at relatively low doses caused distinct tremor in mice and rats. 4. Both compounds also potentiate the convulsant effect induced by mercaptopropionic acid. |
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Authors:
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P H Yu; B A Davis |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 15 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 1991 |
Date Detail:
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Created Date: 1991-09-13 Completed Date: 1991-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 303-6 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amine Oxidase (Copper-Containing)
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metabolism Amines / metabolism*, pharmacology Animals Behavior, Animal / drug effects Brain / enzymology, metabolism Deamination Glycine / analogs & derivatives*, metabolism, pharmacology Hydrogen Peroxide / metabolism Liver / enzymology Mice Monoamine Oxidase / metabolism* Rats Valproic Acid / blood, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amines; 135498-67-8/N-(2-propylpentyl)glycinamide; 40755-21-3/2-propyl-1-aminopentane; 56-40-6/Glycine; 7722-84-1/Hydrogen Peroxide; 99-66-1/Valproic Acid; EC 1.4.3.4/Monoamine Oxidase; EC 1.4.3.6/Amine Oxidase (Copper-Containing) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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