Document Detail


Deamination of 2-propyl-1-aminopentane and 2-[(2-propyl)pentylamino] acetamide by amine oxidases: formation of valproic acid.
MedLine Citation:
PMID:  1908106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. 2-Propyl-1-aminopentane and 2-[(2-propyl)pentylamino]acetamide are deaminated by rat liver monoamine oxidase (MAO) and aorta semicarbazide-sensitive amine oxidase (SSAO). 2. The deaminated product, 2-propylpentaldehyde, is further converted to valproic acid in vitro as well as in vivo. 3. The anticonvulsant action of these two compounds could not be substantiated, because both drugs at relatively low doses caused distinct tremor in mice and rats. 4. Both compounds also potentiate the convulsant effect induced by mercaptopropionic acid.
Authors:
P H Yu; B A Davis
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  15     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1991  
Date Detail:
Created Date:  1991-09-13     Completed Date:  1991-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  303-6     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Descriptor/Qualifier:
Amine Oxidase (Copper-Containing) / metabolism
Amines / metabolism*,  pharmacology
Animals
Behavior, Animal / drug effects
Brain / enzymology,  metabolism
Deamination
Glycine / analogs & derivatives*,  metabolism,  pharmacology
Hydrogen Peroxide / metabolism
Liver / enzymology
Mice
Monoamine Oxidase / metabolism*
Rats
Valproic Acid / blood,  metabolism*
Chemical
Reg. No./Substance:
0/Amines; 135498-67-8/N-(2-propylpentyl)glycinamide; 40755-21-3/2-propyl-1-aminopentane; 56-40-6/Glycine; 7722-84-1/Hydrogen Peroxide; 99-66-1/Valproic Acid; EC 1.4.3.4/Monoamine Oxidase; EC 1.4.3.6/Amine Oxidase (Copper-Containing)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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