Document Detail

Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide: short communication.
MedLine Citation:
PMID:  22955728     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear.
OBJECTIVE: The aim of the present work was to evaluate the effects of red wine fractions (alcoholic and nonalcoholic) on BP and plasma nitric oxide (NO) in subjects at high cardiovascular risk.
METHODS AND RESULTS: Sixty-seven men at high cardiovascular risk were studied. After a 2-week run-in period, subjects were randomized into 3 treatment periods in a crossover clinical trial, with a common background diet plus red wine (30g alcohol/day), the equivalent amount of dealcoholized red wine, or gin (30g alcohol/day), lasting 4 weeks each intervention. At baseline and after each intervention, anthropometrical parameters, BP and plasma NO were measured. Systolic and diastolic BP decreased significantly after the dealcoholized red wine intervention and these changes correlated with increases in plasma NO.
CONCLUSIONS: Dealcoholized red wine decreases systolic and diastolic BP. Our results point out through an NO-mediated mechanism. The daily consumption of dealcoholized red wine could be useful for the prevention of low to moderate hypertension. Trial registered at ISRCTN88720134.
Gemma Chiva-Blanch; Mireia Urpi-Sarda; Emilio Ros; Sara Arranz; Palmira Valderas-Martínez; Rosa Casas; Emilio Sacanella; Rafael Llorach; Rosa M Lamuela-Raventos; Cristina Andres-Lacueva; Ramon Estruch
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-09-06
Journal Detail:
Title:  Circulation research     Volume:  111     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-12-17     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1065-8     Citation Subset:  IM    
Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
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MeSH Terms
Blood Pressure / drug effects*,  physiology
Central Nervous System Depressants / administration & dosage
Cross-Over Studies
Ethanol / administration & dosage
Hypertension / drug therapy*,  epidemiology,  prevention & control
Middle Aged
Nitric Oxide / blood*
Polyphenols / administration & dosage*
Risk Factors
Risk Reduction Behavior
Treatment Outcome
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Polyphenols; 10102-43-9/Nitric Oxide; 64-17-5/Ethanol
Comment In:
Circ Res. 2012 Dec 7;111(12):e388; author reply e389-90   [PMID:  23223933 ]
Circ Res. 2012 Sep 28;111(8):959-61   [PMID:  22955729 ]

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