| Deactivation mechanisms of rod phototransduction: the Cogan lecture. | |
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MedLine Citation:
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PMID: 20185839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods. |
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Authors:
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Marie E Burns |
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Publication Detail:
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Type: Lectures |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 51 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-03-26 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1282-8 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Vision Science and Center for Neuroscience, University of California, Davis, California, USA |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Awards and Prizes Florida Humans Light Mice Mice, Knockout Mice, Transgenic Ophthalmology Retinal Rod Photoreceptor Cells / physiology* Societies, Scientific Vision, Ocular / physiology* Visual Pathways / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY014047-08/EY/NEI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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